通过高强度超声(HIUS)使微粒印迹在腹膜中实现穿透和局部持久治疗腹膜转移。

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2020-08-25 eCollection Date: 2020-01-01 DOI:10.1155/2020/9679385
Agata Mikolajczyk, Tanja Khosrawipour, Alice Martino, Joanna Kulas, Marek Pieczka, Maciej Zacharski, Jakub Nicpon, Veria Khosrawipour
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引用次数: 5

摘要

微粒子和纳米粒子,具有亚微米大小,物理和化学性质的多功能性,易于修改的表面,是独特的定位,绕过身体的清除系统。然而,微粒子和纳米粒子的两个主要问题限制了其腹腔内应用。本研究旨在评估HIUS是否能使微粒印迹,从而增强其在腹膜中的穿透性和局部持久性。方法:采用20千赫兹、输出功率70 W的高强度超声(HIUS)对新鲜死猪腹膜组织进行不同时间间隔的超声检测。在HIUS应用之前,样品表面覆盖有铝酸锶微粒,然后通过电子显微镜进行分析。用荧光显微镜在冷冻薄片上测量组织内铝酸锶的渗透和颗粒分布尺寸。结果:随着HIUS时间的增加(1分钟vs 5分钟),腹膜中检测到铝酸锶颗粒的增加。HIUS导致颗粒选择过程,主要增强小颗粒的穿透,而大颗粒则难以穿透腹膜。更小的颗粒进入腹膜277µm±86µm。结论:我们的数据表明,HIUS可以作为制备微粒子和纳米粒子的腹膜组织的方法。在不增加施用物质的情况下,可以获得更高的组织穿透率和更长的局部耐力。需要进行更多的研究来分析HIUS在加强腹腔药物应用方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Enabling Microparticle Imprinting to Achieve Penetration and Local Endurance in the Peritoneum via High-Intensity Ultrasound (HIUS) for the Treatment of Peritoneal Metastasis.

Introduction: Micro- and nanoparticles, with their submicron size, the versatility of physical and chemical properties, and easily modifiable surface, are uniquely positioned to bypass the body's clearing systems. Nonetheless, two main problems with micro- and nanoparticles arise which limit the intraperitoneal application. The study was performed to evaluate whether HIUS enables the imprinting of microparticles and, therefore, enhances penetration and local endurance in the peritoneum.

Methods: High-intensity ultrasound (HIUS) at 20 kilohertz with an output power of 70 W was applied on peritoneal tissue samples from fresh postmortem swine for different time intervals. Before the HIUS application, the surface of the samples was covered with strontium aluminate microparticles before analysis via electron microscopy. In-tissue strontium aluminate penetration and particle distribution size were measured using fluorescence microscopy on frozen thin sections.

Results: With increasing HIUS durations (1 versus 5 minutes), increasing strontium aluminate particles were detected in the peritoneum. HIUS leads to a particle selection process with enhancing predominantly the penetration of smaller particles whereas larger particles had a harder time penetrating the peritoneum. Smaller particles were detected up to 277 µm ± 86 µm into the peritoneum.

Conclusion: Our data indicate that HIUS might be used as a method to prepare the peritoneal tissue for micro- and nanoparticles. Higher tissue penetration rates without the increase and longer local endurance of the applied substance could be reached. More studies need to be performed to analyze the effect of HIUS in enhancing intraperitoneal drug applications.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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