巴西蛇麻科:毒理学观点。

IF 1.8 3区 医学 Q4 TOXICOLOGY Journal of Venomous Animals and Toxins Including Tropical Diseases Pub Date : 2021-11-22 eCollection Date: 2021-01-01 DOI:10.1590/1678-9199-JVATITD-2021-0004
Keven Wender Rodrigues Macedo, Lucas Jeferson de Lima Costa, Jéssica Oliveira de Souza, Isadora Alves de Vasconcelos, Jessica Schneider de Castro, Carlos José Correia de Santana, Ana Carolina Martins Magalhães, Mariana de Souza Castro, Osmindo Rodrigues Pires
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引用次数: 1

摘要

兽齿科包括Mygalomorphae次目中数量最多的物种,目前已编目的物种有数百种。然而,在生理甚至生态方面的信息却非常缺乏,尤其是在巴西这个世界上生物多样性最丰富的国家。多年来,蜘蛛被认为是多种具有基本作用的生物活性化合物的来源,例如对病原微生物的初级防御或代谢途径的调节,以及作为专门的猎人。蜘蛛毒液也在进化,以便通过与多种感兴趣的分子靶点相互作用来捕获猎物,从而提高其开发新药的制药潜力。从巴西蛇毒科毒液和血细胞中分离的化合物中发现的活性有抗菌、抗真菌、抗寄生虫和抗肿瘤,以及与蛋白酶作用和由离子电压门控通道相互作用调节的神经肌肉阻塞有关的特性。这些特征存在于多个属的不同物种中,这是蜘蛛生存中重要作用的有力证据。本综述的目的是汇编近几十年来对巴西蛇毒科的主要研究结果,特别侧重于从粗毒液或从毒液和血细胞中分离的化合物中获得的结果,以及它们的生理和化学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Brazilian Theraphosidae: a toxicological point of view.

The Theraphosidae family includes the largest number of species of the Mygalomorphae infraorder, with hundreds of species currently catalogued. However, there is a huge lack on physiologic and even ecologic information available, especially in Brazil, which is the most biodiverse country in the world. Over the years, spiders have been presented as a source of multiple biologically active compounds with basic roles, such as primary defense against pathogenic microorganisms or modulation of metabolic pathways and as specialized hunters. Spider venoms also evolved in order to enable the capture of prey by interaction with a diversity of molecular targets of interest, raising their pharmaceutical potential for the development of new drugs. Among the activities found in compounds isolated from venoms and hemocytes of Brazilian Theraphosidae there are antimicrobial, antifungal, antiparasitic and antitumoral, as well as properties related to proteinase action and neuromuscular blockage modulated by ionic voltage-gated channel interaction. These characteristics are present in different species from multiple genera, which is strong evidence of the important role in spider survival. The present review aims to compile the main results of studies from the last decades on Brazilian Theraphosidae with special focus on results obtained with the crude venom or compounds isolated from both venom and hemocytes, and their physiological and chemical characterization.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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