抗微生物肽的肺部输送系统。

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-09-20 DOI:10.1080/07388551.2023.2254932
Lucrezia Caselli, Gisele R Rodrigues, Octavio L Franco, Martin Malmsten
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引用次数: 0

摘要

呼吸道细菌感染每年造成数百万人死亡。存在几种疾病,其中(1)细菌感染是疾病的主要原因(例如,肺结核和细菌性肺炎),(2)细菌感染为疾病的后果并恶化疾病预后(例如,囊性纤维化),以及(3)细菌引发的炎症传播疾病(例如,慢性阻塞性肺病)。目前对抗感染的方法通常包括长期和积极的抗生素治疗,这挑战了患者的依从性,从而使复发变得常见,并导致抗生素耐药性的发展。因此,无法用传统抗生素治疗的感染比例正在迅速增加,迫切需要新的治疗方法。在这种情况下,抗微生物肽(AMP)受到了相当大的关注,因为它们可能对抗生素耐药菌株表现出强大的抗微生物作用,但毒性适中。此外,一些AMP抑制炎症并提供其他宿主防御功能(激发替代术语宿主防御肽(HDPs))。然而,AMPs的递送是复杂的,因为它们是大的、带正电的和两亲性的。因此,AMP递送系统最近引起了关注。对于呼吸道感染,目前研究的递送方法从气溶胶和干粉到各种自组装和纳米颗粒载体系统,以及它们的组合。在这篇论文中,我们讨论了该领域的最新进展,从作用机制研究到这些系统在对抗呼吸道细菌感染方面的应用。
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Pulmonary delivery systems for antimicrobial peptides.

Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional antibiotics is rapidly increasing, and novel therapies are urgently needed. In this context, antimicrobial peptides (AMPs) have received considerable attention as they may exhibit potent antimicrobial effects against antibiotic-resistant bacterial strains but with modest toxicity. In addition, some AMPs suppress inflammation and provide other host defense functions (motivating the alternative term host defense peptides (HDPs)). However, the delivery of AMPs is complicated because they are large, positively charged, and amphiphilic. As a result of this, AMP delivery systems have recently attracted attention. For airway infections, the currently investigated delivery approaches range from aerosols and dry powders to various self-assembly and nanoparticle carrier systems, as well as their combinations. In this paper, we discuss recent developments in the field, ranging from mechanistic mode-of-action studies to the application of these systems for combating bacterial infections in the airways.

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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
期刊最新文献
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