限制热量饮食干预对睡眠不足的肥胖患者减肥和肠道微生物群多样性的影响。

Surong Wen, Yaojun Ni, Yuhong Dai, Ziyu Liu, Xiaoqing Wang, Jie Zhang, Weinan Yu, Wen Hu
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引用次数: 0

摘要

目的:本研究旨在探讨热量限制饮食(CRD)干预对睡眠剥夺(SD)肥胖患者体重和肠道微生物群多样性的影响。方法:将20名肥胖患者分为睡眠剥夺组(SD组 = 10) 非睡眠剥夺组(NSD组 = 10) ,均接受了为期12周的CRD干预。在基线和第12周结束时进行人体测量参数、生化检查和肠道微生物群检测。Mi Smart Bands 1(标准选项)用于监测睡眠和运动。结果:(1)CRD干预改善了所有肥胖患者的体重(BW)、腰围(WC)、血压(BP)、基础代谢率(BMR)、体脂含量(BFC)和胰岛素抵抗指数(HOMA-IR)。(2) 在NSD组中,CRD干预后BW、BFC、VFA(内脏脂肪面积)、BMR和总胆固醇(TC)显著降低(P 结论:CRD干预对减肥的影响减弱,SD可能会削弱血脂代谢。软体动物门细菌的丰度可能与肥胖患者CRD干预后的减肥有关。证据水平:III,前瞻性队列研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effects of a calorie-restricted dietary intervention on weight loss and gut microbiota diversity in obese patients with sleep deprivation.

Objectives: This study aimed to investigate the effects of a calorie-restricted dietary (CRD) intervention on weight and gut microbiota diversity in obese patients with sleep deprivation (SD).

Methods: Twenty obese patients were divided into a sleep deprivation group (SD group, n = 10) and a nonsleep deprivation group (NSD group, n = 10), both of which underwent a CRD intervention for 12 weeks. Measurement of anthropometric parameters, biochemical examinations and gut microbiota detection were performed at baseline and at the end of week 12. Mi Smart Bands 1 (Standard Option) were used to monitor sleep and exercise.

Results: (1) The CRD intervention improved body weight (BW), waist circumference (WC), blood pressure (BP), basal metabolic rate (BMR), body fat content (BFC), and insulin resistance index (HOMA-IR) in all obese patients. (2) In the NSD group, BW, BFC, VFA (visceral fat area), BMR and total cholesterol (TC) were significantly reduced after the CRD intervention (P < 0.05). (3) The alpha diversity of the gut microbiota remained unchanged after the intervention in the two groups. (4) There was a negative correlation between Mollicutes and BMR in the NSD group.

Conclusions: The effects of a CRD intervention weaken on weight loss and the metabolism of blood lipids may be weakened by SD. The abundance of Mollicutes bacteria may be related to weight loss after a CRD intervention in obese patients.

Level of evidence: III, prospective cohort study.

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来源期刊
CiteScore
6.50
自引率
10.30%
发文量
170
审稿时长
>12 weeks
期刊介绍: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.
期刊最新文献
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