宫颈扩张球囊和蓖麻油餐护理干预足月引产的临床效果

Juan Xie, Zhijuan Zhang, Xiaofeng Xu
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引用次数: 0

摘要

本研究分析了宫颈扩张球囊和蓖麻油餐护理干预足月引产的临床效果。使用随机数表将计划于2020年3月至2022年1月在我院分娩的80名孕妇分为观察组和对照组。对照组给予催产素引产,观察组给予宫颈扩张球囊及蓖麻油餐护理干预引产。除了临床治疗实验外,还进行了细胞实验。培养BeWo细胞,研究雌激素对细胞活力的影响,并用蛋白质印迹法检测基质金属蛋白酶2和9(MMP2,MMP9)的表达。本研究的终点是调查雌激素变化对足月妊娠妇女的影响,并比较宫颈扩张球囊和蓖麻油餐护理干预在分娩持续时间、宫颈成熟效果、宫颈Bishop评分、产后并发症和其他相关指标方面的效果。不同浓度的17β-E2处理后BeWo细胞活力无显著性差异(P>0.05),MMP9表达无显著性差别(P>0.05),而MMP2蛋白在5×10-7和5×10-8M治疗组中的表达低于对照组(P<0.05)。观察组的第一产程和总产程明显短于对照组(P<0.05)(P<0.05)。干预后观察组宫颈Bishop评分明显高于对照组(P<0.05),并发症发生率明显低于对照组(P<0.01)。雌激素水平可能影响滋养层细胞的侵袭功能,导致胎盘功能异常。蓖麻油具有激素作用,含有前列腺素合成的前体,可以诱导和加强宫缩,软化宫颈,扩张宫颈。宫颈扩张球囊和蓖麻油粉联合应用于足月引产具有明显的临床效果,包括有效缩短产程,有利于宫颈成熟,显著改善宫颈Bishop评分,降低并发症发生率。这项研究表明它具有临床应用和更广泛应用的潜力。
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Clinical Effects of Cervical Dilation Balloon and Castor Oil Meal Nursing Interventions in Term Induction of Labor
This study analyzed the clinical effects of cervical dilation balloon and castor oil meal nursing interventions in term induction of labor. The eighty pregnant women who were scheduled for delivery in our hospital between March 2020 and January 2022 were recruited into an observation group and a control group using a random number table. The control group received oxytocin for labor induction while the observation group received cervical dilation balloon and castor oil meal nursing interventions for labor induction. In addition to clinical treatment experiments, cell experiments are performed. BeWo cells were cultured to study the effect of estrogen on cell viability, and the expression of matrix metalloproteinase 2 and 9 (MMP2, MMP9) was detected using Western blotting. The endpoints of this study were to investigate the impact of estrogen changes on term-induced pregnant women and to compare the cervical dilation balloon and castor oil meal nursing interventions with regards to duration of labor, efficacy of cervical ripening, Bishop score of the cervix, postpartum complications, and other relevant indicators. The viability of BeWo cells did not significantly differ after treatment with different concentrations of 17β-E2 (-> 0.05). The expression of MMP9 after different levels of treatment did not significantly differ (P >0.05), whereas the expression of MMP2 protein in the 5×10−7 and 5×10−8 M treatment groups was lower than that in the control group (P <0.05). The first stage and total duration of labor were significantly shorter in the observation group than that in the control group (P <0.05). The efficacy of cervical ripening was significantly higher in the observation group than that in the control group (P <0.05). The Bishop score of the cervix was significantly higher in the observation group after intervention (P <0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P <0.05). Estrogen levels may affect the invasive function of trophoblast cells, causing abnormal placental function. Castor oil has hormonal effects and contains precursors for prostaglandin synthesis and can induce and strengthen contractions, soften the cervix, and dilate the cervix. The combined use of cervical dilation balloon and castor oil meal in term induction of labor has clear clinical effects, including the effective shortening of labor duration, favorable cervical ripening, significant improvement in the Bishop score of the cervix, and reduced incidence of complications. This study suggests its potential for clinical application and wider use.
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来源期刊
Journal of Biobased Materials and Bioenergy
Journal of Biobased Materials and Bioenergy 工程技术-材料科学:生物材料
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发文量
60
审稿时长
6 months
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