竞争对手诱导的基于碳量子点的分级囊泡自组装耗散:一种治疗高胆固醇血症的纳米平台

Q3 Materials Science JCIS open Pub Date : 2023-10-01 DOI:10.1016/j.jciso.2023.100094
Saheli Sarkar, Subhro Mandal, Animesh Pramanik
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引用次数: 0

摘要

来自两亲分子的超分子自组装是主要兴趣之一,其动机是开发新的构建块来创建不同的任务特异性自组装。考虑到这些自聚集体在全球范围内的新兴适用性,有必要开发一种使用新型构建块制造自聚集体的替代技术。为此,我们合成了棕榈酰部分功能化碳量子点(FCQD)。有趣的是,合成的FCQD与“宿主”β-环糊精(βCD)形成稳定的两亲性包合物(βCD-FCQD)。这种两亲性的βCD-FCQD复合物被用作构建块,形成分层的囊泡自聚集体(βCD-FCQD囊泡)。结果该βCD-FCQD囊泡可用于胆固醇检测。此外,降胆固醇亲水性药物瑞舒伐他汀装载βCD-FCQD囊泡被发现具有潜在的胆固醇调节作用。这项工作有望鼓励基于药物负载自组装的配方的构建,从而实现对高胆固醇血症等胆固醇相关疾病的分级联合治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Competitor induced dissipation of carbon quantum dot based hierarchical vesicular self-assembly: A theranostic nanoplatform towards hypercholesterolemia

Hypothesis

Supramolecular self-assembly derived from amphiphilic molecules is one of the prime interests with the motivation to develop new building blocks to create different task-specific self-assemblies. Considering the emergent applicability of these self-aggregates across the globe, it would be necessary to develop an alternate technique for the manufacture of self-aggregates employing novel building blocks.

Experiment

With this aim, we synthesized a palmitoyl moiety functionalized carbon quantum dot (FCQD). Interestingly, the synthesized FCQD was found to form a stable amphiphilic inclusion complex (βCD-FCQD) with the ‘host’ β-cyclodextrin (βCD). This amphiphilic βCD-FCQD complex was utilized as a building block to form a hierarchical vesicular self-aggregate (βCD-FCQD vesicle).

Findings

This βCD-FCQD vesicle was successfully employed to detect cholesterol. Moreover, cholesterol lowering hydrophilic drug rosuvastatin loaded βCD-FCQD vesicle was found to be potential in regulation of cholesterol. This work is anticipated to encourage the construction of drug loaded self-assembly based formulation to achieve a way out towards graded combined treatment for cholesterol related disorder like hypercholesterolemia.

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来源期刊
JCIS open
JCIS open Physical and Theoretical Chemistry, Colloid and Surface Chemistry, Surfaces, Coatings and Films
CiteScore
4.10
自引率
0.00%
发文量
0
审稿时长
36 days
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