{"title":"增材制造人工骨支架和骨关节的研究进展","authors":"Khanish Gupta, Kusum Meena","doi":"10.1016/j.bprint.2023.e00268","DOIUrl":null,"url":null,"abstract":"<div><p><span>Patients with diseased/damaged bones are increasingly in need of bone replacement, tissue regeneration<span>, and organ repairs. The shape and size of the injury vary from person to person; thus the customized medical implant is a novel technique that has gained interest in recent times which offers personalized </span></span>implants<span><span> to each individual. Additive manufacturing<span> has considerable promise as an efficient fabrication technique for fabricating </span></span>customized implants<span><span><span><span><span> with complicated shapes or for fabricating implants for different sited inside the human body. Through cost-effectiveness, efficiency, and better patient outcomes, this method is expected to change healthcare in the near future. Researchers are using various biomaterials to fabricate orthopedic implants using different additive manufacturing techniques such as </span>fused deposition modelling (FDM), </span>stereolithography<span> (SLA), selective laser sintering (SLS), </span></span>selective laser melting<span> (SLM), selective electron beam melting<span> (SEBM), binder jetting printing (BJP), and direct energy deposition (DED) for the fabrication of the customized implants. The biomaterials and various additive manufacturing techniques employed in current </span></span></span>bone tissue engineering<span> implants are overviewed herein, along with their challenges and future direction. Moreover, multiple factors such as material compositions, surface properties, or process parameters are discussed, which significantly alters the properties of the fabricated scaffold<span>. Lastly, various commercially available products and devices available for bone and bone joint implants fabricated using conventional techniques have also been discussed in this study. No AM-based implant commercialized products are available in the market to date, which shows the incredible urge for research in such an area. Based on the finding of this study, additive manufacturing has demonstrated enormous potential for providing a pathway for the fabrication of customized implants. However, certain difficulties still need to be resolved to accelerate its translation into the clinics.</span></span></span></span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Artificial bone scaffolds and bone joints by additive manufacturing: A review\",\"authors\":\"Khanish Gupta, Kusum Meena\",\"doi\":\"10.1016/j.bprint.2023.e00268\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Patients with diseased/damaged bones are increasingly in need of bone replacement, tissue regeneration<span>, and organ repairs. The shape and size of the injury vary from person to person; thus the customized medical implant is a novel technique that has gained interest in recent times which offers personalized </span></span>implants<span><span> to each individual. Additive manufacturing<span> has considerable promise as an efficient fabrication technique for fabricating </span></span>customized implants<span><span><span><span><span> with complicated shapes or for fabricating implants for different sited inside the human body. Through cost-effectiveness, efficiency, and better patient outcomes, this method is expected to change healthcare in the near future. Researchers are using various biomaterials to fabricate orthopedic implants using different additive manufacturing techniques such as </span>fused deposition modelling (FDM), </span>stereolithography<span> (SLA), selective laser sintering (SLS), </span></span>selective laser melting<span> (SLM), selective electron beam melting<span> (SEBM), binder jetting printing (BJP), and direct energy deposition (DED) for the fabrication of the customized implants. The biomaterials and various additive manufacturing techniques employed in current </span></span></span>bone tissue engineering<span> implants are overviewed herein, along with their challenges and future direction. Moreover, multiple factors such as material compositions, surface properties, or process parameters are discussed, which significantly alters the properties of the fabricated scaffold<span>. Lastly, various commercially available products and devices available for bone and bone joint implants fabricated using conventional techniques have also been discussed in this study. No AM-based implant commercialized products are available in the market to date, which shows the incredible urge for research in such an area. Based on the finding of this study, additive manufacturing has demonstrated enormous potential for providing a pathway for the fabrication of customized implants. However, certain difficulties still need to be resolved to accelerate its translation into the clinics.</span></span></span></span></p></div>\",\"PeriodicalId\":37770,\"journal\":{\"name\":\"Bioprinting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioprinting\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405886623000118\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Computer Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
Artificial bone scaffolds and bone joints by additive manufacturing: A review
Patients with diseased/damaged bones are increasingly in need of bone replacement, tissue regeneration, and organ repairs. The shape and size of the injury vary from person to person; thus the customized medical implant is a novel technique that has gained interest in recent times which offers personalized implants to each individual. Additive manufacturing has considerable promise as an efficient fabrication technique for fabricating customized implants with complicated shapes or for fabricating implants for different sited inside the human body. Through cost-effectiveness, efficiency, and better patient outcomes, this method is expected to change healthcare in the near future. Researchers are using various biomaterials to fabricate orthopedic implants using different additive manufacturing techniques such as fused deposition modelling (FDM), stereolithography (SLA), selective laser sintering (SLS), selective laser melting (SLM), selective electron beam melting (SEBM), binder jetting printing (BJP), and direct energy deposition (DED) for the fabrication of the customized implants. The biomaterials and various additive manufacturing techniques employed in current bone tissue engineering implants are overviewed herein, along with their challenges and future direction. Moreover, multiple factors such as material compositions, surface properties, or process parameters are discussed, which significantly alters the properties of the fabricated scaffold. Lastly, various commercially available products and devices available for bone and bone joint implants fabricated using conventional techniques have also been discussed in this study. No AM-based implant commercialized products are available in the market to date, which shows the incredible urge for research in such an area. Based on the finding of this study, additive manufacturing has demonstrated enormous potential for providing a pathway for the fabrication of customized implants. However, certain difficulties still need to be resolved to accelerate its translation into the clinics.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.