中毒性结节性甲状腺肿患者甲状腺恶性肿瘤的发生率及危险因素分析

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2022-05-23 DOI:10.1155/2022/1054297
T. Mohamed, A. Sultan, M. Tag El-Din, Ahmed A. Elfattah Mostafa, M. Nafea, Abd-Elfattah Kalmoush, Mohammed Shaaban Nassar, Mohamad Adel Abdalgaleel, A. Hegab, A. H. Ibrahim, Mohamad Baheeg
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The collected data included patients age, gender, systemic comorbidities, family history of thyroid malignancy, previous neck radiation, type of disease (multinodular or single), size of the dominant nodule by the US, operative time, and detection of significant lymph nodes during operation. Based on the histopathological analysis, the cases were allocated into benign and malignant groups. Results Malignancy was detected in 21 patients (21.43%). Although age distribution was comparable between the two groups, males showed a significant increase in association with malignancy. Medical comorbidities and family history of cancer did not differ between the two groups. However, TMNG showed a statistically higher prevalence in the malignant group. Operative data, including operative time and lymph node detection, were comparable between the two groups. On regression analysis, both male gender and TMNG were significant predictors of malignancy. 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引用次数: 2

摘要

虽然甲状腺功能亢进被认为对恶性肿瘤有保护作用,但最近的一些研究报道,良性甲状腺功能亢进患者偶然发现癌症的发生率很高。我们进行这项研究是为了估计中毒性结节性甲状腺肿(TNG)患者恶性甲状腺疾病的发生率和预测因素。患者和方法。本文回顾了98例诊断为TNG的患者的资料(包括毒性多结节性甲状腺肿SMNG和单一毒性结节性甲状腺肿STN)。收集的资料包括患者的年龄、性别、全身性合并症、甲状腺恶性家族史、既往颈部放疗、疾病类型(多结节或单发)、超声检查优势结节大小、手术时间、术中有无明显淋巴结。根据组织病理学分析,将病例分为良性组和恶性组。结果恶性肿瘤21例(21.43%)。尽管两组之间的年龄分布相似,但男性与恶性肿瘤的相关性显著增加。医学合并症和癌症家族史在两组之间没有差异。然而,TMNG在恶性组的患病率在统计学上更高。两组的手术数据,包括手术时间和淋巴结检测,具有可比性。在回归分析中,男性性别和TMNG都是恶性肿瘤的显著预测因子。结论甲状腺功能亢进并不是预防恶性肿瘤的保护因素,约1/5的病例可检出恶性肿瘤。男性和TMNG是此类患者发生恶性肿瘤的重要危险因素。
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Incidence and Risk Factors of Thyroid Malignancy in Patients with Toxic Nodular Goiter
Background Although hyperfunctioning thyroid disorders were thought to be protective against malignancy, some recent studies reported a high incidence of incidentally discovered cancer in patients with hyperfunctioning benign thyroid disorders. We performed this study to estimate the incidence and predictors of malignant thyroid disease in patients with toxic nodular goiter (TNG). Patients and Methods. The data of 98 patients diagnosed with TNG were reviewed (including toxic multinodular goiter SMNG and single toxic nodule STN). The collected data included patients age, gender, systemic comorbidities, family history of thyroid malignancy, previous neck radiation, type of disease (multinodular or single), size of the dominant nodule by the US, operative time, and detection of significant lymph nodes during operation. Based on the histopathological analysis, the cases were allocated into benign and malignant groups. Results Malignancy was detected in 21 patients (21.43%). Although age distribution was comparable between the two groups, males showed a significant increase in association with malignancy. Medical comorbidities and family history of cancer did not differ between the two groups. However, TMNG showed a statistically higher prevalence in the malignant group. Operative data, including operative time and lymph node detection, were comparable between the two groups. On regression analysis, both male gender and TMNG were significant predictors of malignancy. Conclusion The presence of thyroid hyperfunction is not a protective factor against malignancy, as malignancy was detected in about 1/5 of cases. Male gender and TMNG were significant risk factors of malignancy in such patients.
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
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