G. Martin, Nainita Roy, Sohini Chakraborty, A. Desrichard, S. Chung, Carolien M Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, J. Hamann, S. Devlin, T. Chan, Christopher Y. Park
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CD97 is a critical regulator of acute myeloid leukemia stem cell function
Martin et al. demonstrate that CD97 is a critical regulator of leukemia stem cell (LSC) function. CD97 is overexpressed in the vast majority of AML patients and promotes AML blast growth, survival, and differentiation. Collectively, these data credential CD97 as a novel and promising therapeutic target in AML.
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