具有8,640个电极的微电极阵列,可同时以6.5 kfps的速度读出全帧,并以20 kS/s的速度读出112通道开关矩阵

X. Yuan, S. Kim, J. Juyon, M. D'Urbino, Torsten Bullmann, Yihui Chen, A. Stettler, A. Hierlemann, U. Frey
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引用次数: 14

摘要

CMOS微电极阵列允许记录数千个位置的神经元。在这里,我们介绍了“双模式操作”微电极阵列的概念,利用全帧扫描和开关矩阵阵列架构的优势到单个器件中。该芯片采用0.18 μm CMOS工艺制备。在每通道功耗分别为3.3 μW和38.1 μW时,全帧扫描和开关矩阵模式下的实测噪声水平分别为11.1 μVrms和1.6 μVrms。已经成功地进行了培养神经元的电活动记录。
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A microelectrode array with 8,640 electrodes enabling simultaneous full-frame readout at 6.5 kfps and 112-channel switch-matrix readout at 20 kS/s
CMOS microelectrode arrays allow for recording from neurons at thousands of sites. Here, we introduce the concept of a `dual-mode operation' microelectrode array, leveraging the advantages of full-frame scanning and switch-matrix array architectures into a single device. The chip was fabricated in 0.18 μm CMOS technology. Measured noise levels were 11.1 μVrms for full-frame scanning and 1.6 μVrms for switch-matrix mode at 3.3 μW and 38.1 μW per channel power consumption. Recordings of electrical activity from cultured neurons have been successfully conducted.
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