橙皮苷在不锈钢表面的固定化及其血液相容性

An J. Li
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引用次数: 4

摘要

将中药橙皮苷包被固定在心血管植入材料常用的不锈钢表面,并对其体外血液相容性进行了评价。与不锈钢对照相比,固定化涂层的活化部分凝血活素时间(APTT)、凝血酶原时间(PT)和凝血酶时间(TT)均有所延长。橙皮苷涂层的血小板粘附和活化试验数据也明显少于对照组。纤维蛋白原(fgn)构象变化测试表明,与裸SS相比,橙皮苷包被可以降低该参数。可见,橙皮苷包被可以有效提高SS表面的血液相容性。我们设想这种涂层将为血液接触装置提供潜在和有效的选择。
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Immobilization of hesperidin on stainless steel surfaces and its blood compatibility

The coating of hesperidin, a traditional Chinese medicine ingredient, was immobilized to the surface of stainless steel (SS) which was often used in the cardiovascular implant materials and evaluated for its blood compatibility in vitro. The immobilized coating showed prolonged activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) values compared with stainless steel control. The platelet adhesion and activation test on the hesperidin coating also showed significantly less data compared with the control. The test on conformational change of fibrinogen (fgn) demonstrated the hesperidin coating could reduce this parameter compared with the bare SS. It can be summarized that the hesperidin coating can effectively improve the blood compatibility of the SS surface. We envisage that this coating will provide a potential and effective selection for blood contact devices.

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