双组份自体纤维蛋白胶羊膜成形术治疗翼状胬肉的效果

Y. Kozlova, S. V. Churashov, A. Kulikov, A. Malafeeva
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摘要

治疗翼状胬肉的唯一有效方法是用不同组织(包括羊膜)进行缺损切除。固定方法的选择将确保最大的效率和最小的复发风险仍然是实际的。使用缝线增加了手术时间,导致患者术后不适。比较分析了我们设计的双组分自体纤维蛋白胶与缝线固定羊膜的手术治疗效果。本研究纳入32例患者,根据羊膜固定方法分为两组:第一组为主组(22例),采用双组分自体纤维蛋白胶固定羊膜;第二组(10例)为对照组,采用缝线固定羊膜。所有患者术前、术后均行生物显微镜及前段光学相干断层扫描,比较两组手术时间、上皮化及康复时间、术后不适情况。在12个月的观察中评估研究组中翼状胬肉复发的情况。在我们的研究中,我们发现组间差异有统计学意义,这表明双组分自体纤维蛋白胶固定羊膜的优势。在12个月的观察中,1例复发采用缝合固定。这使得在翼状胬肉手术中选择双组分自体纤维蛋白胶作为羊膜固定方法成为可能。关键词:翼状胬肉;自体纤维蛋白胶;手术治疗
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The results of amnioplasty using two-component autofibrin glue in surgical treatment of pterygium
The only effective way of pterygium treatment is its removal with defect plasty by different tissues, including amniotic membrane. The choice of fixation method that will ensure maximum efficiency and minimize recurence risk remains actual. Using sutures increases operation time and leads to discomfort of patient in postoperative period. A comparative analysis of effectiveness of surgical treatment using designed by us two-component autofibrin glue and sutures for fixing the amniotic membrane was done. The study included 32 patients, they were divided into 2 groups depending on the method of fixing the amniotic membrane: the 1st group was the main group (22 patients), where the amniotic membrane was fixed with a two-component autofibrin glue, the 2nd group (10 patients) was the control group, where the sutures were used. Before and after surgery all patients underwent biomicroscopy and optical coherence tomography of the anterior segment, the groups were compared by the time spent on the operation, duration of epithelization and rehabilitation, as well as presence of discomfort in postoperative period. The presence of pterygium recurrence in the study groups was assessed during 12-month observation. During our study we found statistically significant differences between groups, which show the advantages of fixing amniotic membrane with two-component autofibrin glue. During 12-month observation one case of recurrence was fixed after using fixation by sutures. This makes possible to choose two-component autofibrin glue as a fixation method of amniotic membrane in pterygium surgery. Keywords: pterygium, autofibrin glue, surgical treatment, amniotic membrane, fixation
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