富多糖山茱萸提取物的抗炎、抗血管生成及抗氧化活性

Allisson Jhonathan Gomes Castro , Luiza Sheyla E.P. Will Castro , Marília S. Nascimento Santos , Monique G.C. Faustino , Thuane S. Pinheiro , Celina M.P. Guerra Dore , Iuri G. Baseia , Edda Lisboa Leite
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引用次数: 17

摘要

富葡聚糖提取液的抗水肿活性高于非甾体抗炎药(NSAIDs)、吲哚美辛和帕瑞昔布。ppara受体激动剂为90.8±10.9%,ppara受体激动剂罗格列酮为41.9±7.1%。实验动物模型,卡拉胶性胸膜炎,发现这种多糖也显示出抗炎作用。除了少量一氧化氮产生外,白细胞迁移也发生严重减少。该聚合物抗血管生成活性表现出较高的抑制浓度(1000 μg/卵)。研究了其总抗氧化活性(57±0.3%)、还原能力(37.6±0.16)和脂质过氧化能力(84±0.51%)。对羟基自由基的抑制作用为38.0±0.01% (1 mg/mL),对铁螯合有较高的抑制作用。结果表明,山茱萸β-葡聚糖含量在炎症模型、血管生成和自由基抑制中具有显著的药理活性。
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Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

Extract rich in glucans from the Caripia montagnei mushroom showed an anti-edematous activity higher than the non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and parecoxib. Agonists of PPARα showed a value of 90.8 ± 10.9% and roziglitazone, an agonist of PPARy, exhibited 41.9 ± 7.1%. An experimental animal model, carrageenan-induced pleurisy, found that this polysaccharide also displayed an anti-inflammatory effect. Severe reductions occur in leukocyte migration, in addition to modest nitric oxide production. The polymer antiangiogenic activity showed a high inhibiting concentration of 1000 μg/egg. This study also investigated total antioxidant activity (57 ± 0.3%), reducing power (37.6 ± 0.16), and lipid peroxidation (84 ± 0.51%) of these polysaccharides. Inhibition of hydroxyl radical was 38.0 ± 0.01% (1 mg/mL), with high inhibition of iron chelation. Results showed that β-glucan content from Caripia montagnei has significant pharmacological activity in inflammation models, angiogenesis, and inhibition of free radicals.

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