内皮细胞IQGAP1通过引导LBRC到渗出部位来调节白细胞的转运

The Tokushima journal of experimental medicine Pub Date : 2019-08-08 DOI:10.1084/jem.20190008

D. Sullivan, P. Dalal, F. Jaulin, D. Sacks, G. Kreitzer, W. Muller

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引用次数: 13

摘要

内皮细胞IQGAP1在浸润过程中的功能需要其作用蛋白结合域和IQ基序来招募外侧边界循环室。体内内皮细胞IQGAP1表达的基因消融在两种炎症模型中引起明显的水肿破坏。

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Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis

The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruption of diapedesis in two models of inflammation.

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The Tokushima journal of experimental medicine

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