发育和细胞年龄直接将CD4+ T细胞转化为RORγ+或Helios+结肠Treg细胞

The Tokushima journal of experimental medicine Pub Date : 2019-11-04 DOI:10.1084/jem.20190428

Alvin Pratama, Alexandra Schnell, D. Mathis, C. Benoist

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引用次数: 47

摘要

使用多克隆Treg细胞替代系统，Pratama等人发现幼稚Tconv细胞具有在结肠中转化为RORγ+和Helios+ Treg细胞的能力。起始Tconv细胞的发育成熟度(或细胞状态)决定了产生的pTreg细胞的表型。

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Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

Using a polyclonal Treg cell replacement system, Pratama et al. show that naive Tconv cells have the capacity to convert into both RORγ+ and Helios+ Treg cells in the colon. The developmental maturity (or cell states) of the starting Tconv cells determines the phenotype of the resulting pTreg cells.

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The Tokushima journal of experimental medicine

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