CFIm25的下调通过选择性聚腺苷化放大皮肤纤维化

The Tokushima journal of experimental medicine Pub Date : 2019-11-22 DOI:10.1084/jem.20181384

Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi

{"title":"CFIm25的下调通过选择性聚腺苷化放大皮肤纤维化","authors":"Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi","doi":"10.1084/jem.20181384","DOIUrl":null,"url":null,"abstract":"This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"21","resultStr":"{\"title\":\"Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation\",\"authors\":\"Tingting Weng, Jing-Jing Huang, E. Wagner, Junsuk Ko, Minghua Wu, N. Wareing, Yu Xiang, Ning-yuan Chen, Ping Ji, Jose G. Molina, K. Volcik, Leng Han, M. Mayes, M. Blackburn, S. Assassi\",\"doi\":\"10.1084/jem.20181384\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20181384\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20181384","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 21

摘要

该研究揭示了真皮纤维化和系统性硬皮病发病机制中选择性聚腺苷酸化的关键调节因子CFIm25。CFIm25下调可促进促纤维化因子的表达，加重博来霉素诱导的皮肤纤维化，而CFIm25修复可减轻皮肤纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation

This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Tokushima journal of experimental medicine

自引率

0.00%

发文量