Wensleslace Landry Mve Mendame, Boris Achille Eyi Mintsa, Alban-Michel Nguema Nguema, A. B. Pambo-Pambo, Ibrahim
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Phytochemical screening and effects of aqueous extract of Acalypha wilkesiana Müll. Arg on isolated toad heart
Medicinal plants are real sources of bioactive molecules. The objective of the present study was to assess the effects of aqueous extract of Acalypha wilkesiana (ALWILEXT) on toad heart. Phytochemical screening of the aqueous extract revealed the presence of bioactives, namely: coumarins, flavones, polyphenols, alkaloids, tannins, terpenes and saponosides. The results obtained show that ALWILEXT, at concentrations ranging from 5.10-5 to 5.10-5g / ml, causes negative inotropic and chronotropic effects on the isolated toad heart, similar to those of acetylcholine although less marked. These effects suggest the presence of adrenomimetics in the aqueous extract. The aqueous extract of Acalypha wilkesiana is said to contain concomitantly adrenomimetics which would justify its use in the treatment of hypertension.
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