用于产生纳秒脉冲的高功率mosfet推挽结构用于分离的癌症干细胞的电渗透

2018 48th European Microwave Conference (EuMC) Pub Date : 2018-09-01 DOI:10.23919/EUMC.2018.8541734

I. W. Davies, C. Merla, M. Tanori, A. Zambotti, J. Bishop, C. Palego, C. Hancock

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引用次数: 0

摘要

本文介绍了一种新型电穿孔发生器的仪器和使用，该发生器由mosfet配置为推挽式配置，并带有人工$50\ \Omega$缓冲液，用于可能的实时中和癌症干细胞。最初的实验研究结果调查了一种电穿孔发生器的开发，该发生器能够使用原始的试管外壳单元进行非热处理，以及它对分离的癌症干细胞的影响。对癌症干细胞进行了初步的渗透性研究，表明所开发的方案和设备在实现癌症干细胞的电操作方面具有强大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Push-Pull Configuration of High Power MOSFETs for Generation of Nanosecond Pulses for Electropermeabilization of Isolated Cancer Stem Cells

This paper presents the instrumentation and use of a novel electroporation generator, configured of MOSFETs in a push-pull configuration, with an artificial $50\ \Omega$ buffer for possible real-time neutralization of cancer stem cells. The results from an initial bench study investigates the development of an electroporation generator capable of delivering non-thermal treatment with an original cuvette housing unit and its effects on isolated cancer stem cell. Initial permeabilization investigation of cancer stem cells were conducted, indicating that the developed protocols and devices have a strong potential future use in achieving electro-manipulation of cancer stem cells.

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2018 48th European Microwave Conference (EuMC)

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