Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs

Peoplewithskinlesionscausedbyburns,ulcerationsandothercomplications,independentofdegreeandextensionoftheproblem,hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus,materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility,compositionuniformity,lowcost,longvalidity,flexibility,andsoon.Inthischapter,hydro-philicmembranesbasedonpolyvinylpyrrolidone-PVP/poly(vinylalcohol)-PVAland chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electron-beam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physi- cochemicaltests.Pseudoboehmitenanoparticles wereobtainedfrom aluminumnitrate bya sol – gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling,greaterattractionandgreaterresistancetoelongationatbreakintension,althoughsignificantlylowerfractionofgelmembranescontainsonlyagarandPVP.Itwasverifiedthatthepresenceofchitosannanoparticlesandpseudoboehmitepromotesadecreaseintheformationofcross-linksduringirradiationofhydrophilicmembranes. with higher mechanical properties, the dose irradiation must be increased to increase the density of cross-links.