新型二硫化物作为抗癌/抗疟剂

G. Kong, K. Kain, I. Crandall, R. Langler
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引用次数: 17

摘要

利用体外实验确定了11种小有机硫化合物的抗疟/抗癌(人类皮肤癌)特性,其中一些具有抗真菌和抗白血病活性。一些化合物几乎没有抗疟/抗癌活性,而另一些化合物具有高活性,IC50值在低µM范围内。三种二硫化物(3,7,9)显示出令人鼓舞的活性,即:对CHO(代表性哺乳动物)细胞的活性较低,而对人类疟疾(恶性疟原虫)细胞和人类皮肤癌(C32)细胞的活性显著较高。
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Novel disulfides as anticancer/antimalarial agents
The antimalarial/anticancer (human skin cancer) properties of 11 small organosulfur compounds, some of which show antifungal and antileukemic activity, were determined using in vitro assays. Some compounds had little or no antimalarial/anticancer activity while others were highly active with IC50 values in the low µM range. Three disulfides (3, 7, 9) show encouraging activity, viz: low activity against CHO (representative mammalian) cells and significantly higher activity against human malaria (Plasmodium falciparum) cells and human skin cancer (C32) cells.
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