{"title":"新型二硫化物作为抗癌/抗疟剂","authors":"G. Kong, K. Kain, I. Crandall, R. Langler","doi":"10.1080/02786110310001612272","DOIUrl":null,"url":null,"abstract":"The antimalarial/anticancer (human skin cancer) properties of 11 small organosulfur compounds, some of which show antifungal and antileukemic activity, were determined using in vitro assays. Some compounds had little or no antimalarial/anticancer activity while others were highly active with IC50 values in the low µM range. Three disulfides (3, 7, 9) show encouraging activity, viz: low activity against CHO (representative mammalian) cells and significantly higher activity against human malaria (Plasmodium falciparum) cells and human skin cancer (C32) cells.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2003-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Novel disulfides as anticancer/antimalarial agents\",\"authors\":\"G. Kong, K. Kain, I. Crandall, R. Langler\",\"doi\":\"10.1080/02786110310001612272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antimalarial/anticancer (human skin cancer) properties of 11 small organosulfur compounds, some of which show antifungal and antileukemic activity, were determined using in vitro assays. Some compounds had little or no antimalarial/anticancer activity while others were highly active with IC50 values in the low µM range. Three disulfides (3, 7, 9) show encouraging activity, viz: low activity against CHO (representative mammalian) cells and significantly higher activity against human malaria (Plasmodium falciparum) cells and human skin cancer (C32) cells.\",\"PeriodicalId\":22122,\"journal\":{\"name\":\"Sulfur Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sulfur Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/02786110310001612272\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sulfur Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/02786110310001612272","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Novel disulfides as anticancer/antimalarial agents
The antimalarial/anticancer (human skin cancer) properties of 11 small organosulfur compounds, some of which show antifungal and antileukemic activity, were determined using in vitro assays. Some compounds had little or no antimalarial/anticancer activity while others were highly active with IC50 values in the low µM range. Three disulfides (3, 7, 9) show encouraging activity, viz: low activity against CHO (representative mammalian) cells and significantly higher activity against human malaria (Plasmodium falciparum) cells and human skin cancer (C32) cells.
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