{"title":"香豆素对实验性2型糖尿病大鼠的降血脂作用","authors":"Leelavinothan Pari, Narayanasamy Rajarajeswari, Settu Saravanan, Ayyasamy Rathinam","doi":"10.1016/j.bionut.2014.02.003","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The present study was aimed to examine the hypolipidemic effect of </span>coumarin<span> on streptozotocin–nicotinamide induced type 2 diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 45</span></span> <span>mg/kg streptozotocin, 15</span> <!-->min after the intraperitoneal administration of 110<!--> <span><span><span>mg/kg nicotinamide. Streptozotocin–nicotinamide induced diabetic rats showed a significant increase in the levels of plasma and tissue (liver and kidney) lipids (total cholesterol, </span>triglycerides, free fatty acids, phospholipids), LDL, </span>VLDL<span><span> and a significant decrease in the levels of HDL were observed. A significant increase in the activity of HMG-CoA reductase in tissues and significant decrease in the activities of LPL and LCAT in plasma were observed in type 2 diabetic rats. After oral administration of coumarin to diabetic rats, were found to alleviate the lipid profiles and lipid metabolizing enzymes. Conclusively, oral </span>treatment<span> of coumarin exhibited in a marked antihyperlipidemic effect against diabetes mellitus.</span></span></span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 2","pages":"Pages 171-176"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.02.003","citationCount":"16","resultStr":"{\"title\":\"Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats\",\"authors\":\"Leelavinothan Pari, Narayanasamy Rajarajeswari, Settu Saravanan, Ayyasamy Rathinam\",\"doi\":\"10.1016/j.bionut.2014.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The present study was aimed to examine the hypolipidemic effect of </span>coumarin<span> on streptozotocin–nicotinamide induced type 2 diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 45</span></span> <span>mg/kg streptozotocin, 15</span> <!-->min after the intraperitoneal administration of 110<!--> <span><span><span>mg/kg nicotinamide. Streptozotocin–nicotinamide induced diabetic rats showed a significant increase in the levels of plasma and tissue (liver and kidney) lipids (total cholesterol, </span>triglycerides, free fatty acids, phospholipids), LDL, </span>VLDL<span><span> and a significant decrease in the levels of HDL were observed. A significant increase in the activity of HMG-CoA reductase in tissues and significant decrease in the activities of LPL and LCAT in plasma were observed in type 2 diabetic rats. After oral administration of coumarin to diabetic rats, were found to alleviate the lipid profiles and lipid metabolizing enzymes. Conclusively, oral </span>treatment<span> of coumarin exhibited in a marked antihyperlipidemic effect against diabetes mellitus.</span></span></span></p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":\"4 2\",\"pages\":\"Pages 171-176\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2014.02.003\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210523914000257\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523914000257","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats
The present study was aimed to examine the hypolipidemic effect of coumarin on streptozotocin–nicotinamide induced type 2 diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 45mg/kg streptozotocin, 15 min after the intraperitoneal administration of 110 mg/kg nicotinamide. Streptozotocin–nicotinamide induced diabetic rats showed a significant increase in the levels of plasma and tissue (liver and kidney) lipids (total cholesterol, triglycerides, free fatty acids, phospholipids), LDL, VLDL and a significant decrease in the levels of HDL were observed. A significant increase in the activity of HMG-CoA reductase in tissues and significant decrease in the activities of LPL and LCAT in plasma were observed in type 2 diabetic rats. After oral administration of coumarin to diabetic rats, were found to alleviate the lipid profiles and lipid metabolizing enzymes. Conclusively, oral treatment of coumarin exhibited in a marked antihyperlipidemic effect against diabetes mellitus.
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