设计一种用于浊度-流动注射技术的连续微流体流动池:一种用于活性药物制剂常规分析的新方法

Aktham N Jasim, Nagham S. Turkey, Hussein Fares Abd-Alrazack
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引用次数: 1

摘要

本文介绍了一种基于样品容量为40µL的微流控流池(MFC)的流动注射分析(FIA)方法。钨丝灯将来自典型的2100P便携式浊度计设备的光线通过2.0 mm的圆形侧壁孔径引导到石英流动池中,并从流动池另一侧的相同孔径出现,其中光电二极管阵列(光检测器)检测通过的光线。与具有相同标称路径长度的传统试管(25mm × 60mm圆)相比,该技术将灵敏度提高了4.0左右。这种改进是由于使用了短而窄的内径微流体作为流池,从而减少了物理分散。通过开发一种浊度法来检测纯形式或药物剂量的异丙嗪,对设计的流动池进行了评价。所开发的方法是基于异丙嗪和四苯基硼酸钠(STPB)在酸性介质中反应形成淡黄色离子对缔合物。在最佳流速条件下,异丙嗪的CC曲线为0.5 ~ 90µg mL-1, LOD为0.35µg mL-1 (R2 = 0.9955)。
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Design a continuous microfluidic flow cell for turbidimetric-flow injection technology: A new approach for routine analysis of active pharmaceutical formulations
In this study, a new flow injection analysis (FIA) based on a microfluidic flow cell (MFC) with a sample capacity of 40 µL is described. A Tungsten lamp directs light from a typical 2100P Portable Turbidimeter apparatus into a quartz flow cell through a round sidewall aperture of 2.0 mm and emerges through the identical aperture on the opposite side of the flow cell, where a photodiode array (light detector) detects the passing light. When compared to a traditional cuvette (25 mm x 60 mm round) with the same nominal route length, this technique improves sensitivity by around 4.0. This improvement is due to the use of a short, narrow internal diameter microfluid as the flow cell, which reduces physical dispersion. The designed flow cell has been evaluated by developing a turbidimetric method for the detection of promethazine in pure form or pharmaceutical dosages. The developed method is based on forming of a yellowish ion-pair association complex due to the reaction of promethazine and sodium tetraphenylborate (STPB) in an acidic medium. At the flow optimum conditions, the calibration curve (CC) and the LOD for promethazine were obtained 0.5-90 µg mL-1 and 0.35 µg mL-1, respectively (R2 = 0.9955). 
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