中枢神经系统损伤后皮质脊髓回路重构依赖于神经元活动

The Tokushima journal of experimental medicine Pub Date : 2019-08-07 DOI:10.1084/jem.20181406

P. Bradley, Carmen K. Denecke, Almir Aljović, Anja Schmalz, M. Kerschensteiner, F. Bareyre

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引用次数: 17

摘要

本研究探讨了脊髓损伤后神经元回路重构过程中靶点选择的原则。这表明，重塑轴突在一个活动依赖的竞争过程中选择它们的突触后伙伴，这对损伤后的功能恢复至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity

This study investigates the principles of target selection during the remodeling of neuronal circuits following spinal cord injury. It demonstrates that remodeling axons select their postsynaptic partners in an activity-dependent competitive process that is critical for functional recovery after injury.

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The Tokushima journal of experimental medicine

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