{"title":"瓢虫粪便中的糖模拟生物碱及其显著的α-葡萄糖苷酶抑制活性","authors":"Jian-Yu Lin, Yihai Wang, Xiangjiu He","doi":"10.9734/ACSJ/2016/25834","DOIUrl":null,"url":null,"abstract":"A new sugar-mimic alkaloid, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidineN-glyoxylamide (1) and a novel natural sugar-mimic alkaloid, (2R,3R,4R)-2-[(S)-1,2-dihydroxyethyl]piperidine-3,4diol (2), as well as nine known compounds, were isolated and identified from Faeces bombycis. Compounds 1 and 2 showed remarkable inhibitory activity against α-glucosidase with the IC50 value of 1.9 and 6.2 μM, which were 93.4 and 28.6 potent folds than that of acarbose. The results showed that the sugar-mimic alkaloids from Faeces bombycis exhibit significant and reasonably broad range α-glucosidase inhibitory activity, which may be useful in the prevention of the postprandial hyperglycemia and provide new candidates for the treatment of diabetes mellitus.","PeriodicalId":7399,"journal":{"name":"American Chemical Science Journal","volume":"63 1","pages":"1-9"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Sugar-mimic Alkaloids from Faeces bombycis and Their Pronounced α-Glucosidase Inhibitory Activities\",\"authors\":\"Jian-Yu Lin, Yihai Wang, Xiangjiu He\",\"doi\":\"10.9734/ACSJ/2016/25834\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new sugar-mimic alkaloid, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidineN-glyoxylamide (1) and a novel natural sugar-mimic alkaloid, (2R,3R,4R)-2-[(S)-1,2-dihydroxyethyl]piperidine-3,4diol (2), as well as nine known compounds, were isolated and identified from Faeces bombycis. Compounds 1 and 2 showed remarkable inhibitory activity against α-glucosidase with the IC50 value of 1.9 and 6.2 μM, which were 93.4 and 28.6 potent folds than that of acarbose. The results showed that the sugar-mimic alkaloids from Faeces bombycis exhibit significant and reasonably broad range α-glucosidase inhibitory activity, which may be useful in the prevention of the postprandial hyperglycemia and provide new candidates for the treatment of diabetes mellitus.\",\"PeriodicalId\":7399,\"journal\":{\"name\":\"American Chemical Science Journal\",\"volume\":\"63 1\",\"pages\":\"1-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Chemical Science Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/ACSJ/2016/25834\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Chemical Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/ACSJ/2016/25834","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sugar-mimic Alkaloids from Faeces bombycis and Their Pronounced α-Glucosidase Inhibitory Activities
A new sugar-mimic alkaloid, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidineN-glyoxylamide (1) and a novel natural sugar-mimic alkaloid, (2R,3R,4R)-2-[(S)-1,2-dihydroxyethyl]piperidine-3,4diol (2), as well as nine known compounds, were isolated and identified from Faeces bombycis. Compounds 1 and 2 showed remarkable inhibitory activity against α-glucosidase with the IC50 value of 1.9 and 6.2 μM, which were 93.4 and 28.6 potent folds than that of acarbose. The results showed that the sugar-mimic alkaloids from Faeces bombycis exhibit significant and reasonably broad range α-glucosidase inhibitory activity, which may be useful in the prevention of the postprandial hyperglycemia and provide new candidates for the treatment of diabetes mellitus.
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