{"title":"甲基-2-(n -乙基- n -苯胺)萘啶-3-羧酸酯的简单合成","authors":"Kishore Kumar Anantoju , Giri Tharikoppula , Laxminarayana Eppakayala , Thirumala Chary Maringanti","doi":"10.1016/j.ijcas.2013.07.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To develop an efficient method for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates which is suitable for different naphthyridines.</p></div><div><h3>Methods</h3><p>All reagents used were commercial grade, <sup>1</sup>H NMR spectra were obtained on a varian 400 MHz instrument with TMS as internal standard and chemical shifts are expressed <em>δ</em> ppm solvent used in DMSO-d<sub>6</sub> & CDCl<sub>3</sub> and LC–MS spectrum on a Waters LC–MS spectrometer operating at 70 ev. TLC is performed with E-Merch precoated silica gel plates (60F-254) with iodine as a developing agent. Acme, India silica gel, 60–120 mesh for column chromatography is used. All compounds are purified by column chromatography by using Silica gel (60–120 mesh) eluted with (50:1) dichloromethane in methanol.</p></div><div><h3>Conclusions</h3><p>We have developed an efficient protocol for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates.</p></div>","PeriodicalId":100693,"journal":{"name":"International Journal of Chemical and Analytical Science","volume":"4 3","pages":"Pages 146-148"},"PeriodicalIF":0.0000,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcas.2013.07.008","citationCount":"0","resultStr":"{\"title\":\"A facile synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates\",\"authors\":\"Kishore Kumar Anantoju , Giri Tharikoppula , Laxminarayana Eppakayala , Thirumala Chary Maringanti\",\"doi\":\"10.1016/j.ijcas.2013.07.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To develop an efficient method for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates which is suitable for different naphthyridines.</p></div><div><h3>Methods</h3><p>All reagents used were commercial grade, <sup>1</sup>H NMR spectra were obtained on a varian 400 MHz instrument with TMS as internal standard and chemical shifts are expressed <em>δ</em> ppm solvent used in DMSO-d<sub>6</sub> & CDCl<sub>3</sub> and LC–MS spectrum on a Waters LC–MS spectrometer operating at 70 ev. TLC is performed with E-Merch precoated silica gel plates (60F-254) with iodine as a developing agent. Acme, India silica gel, 60–120 mesh for column chromatography is used. All compounds are purified by column chromatography by using Silica gel (60–120 mesh) eluted with (50:1) dichloromethane in methanol.</p></div><div><h3>Conclusions</h3><p>We have developed an efficient protocol for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates.</p></div>\",\"PeriodicalId\":100693,\"journal\":{\"name\":\"International Journal of Chemical and Analytical Science\",\"volume\":\"4 3\",\"pages\":\"Pages 146-148\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ijcas.2013.07.008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Chemical and Analytical Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0976120913000478\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chemical and Analytical Science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0976120913000478","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的建立一种适用于不同萘啶的甲基-2-(n -乙基- n -苯胺)萘啶-3-羧酸盐的高效合成方法。方法所用试剂均为商品级，在瓦里安400 MHz仪器上以TMS为内标获得1H NMR谱，化学位移用δ ppm表示，溶剂DMSO-d6 &CDCl3和LC-MS光谱在Waters LC-MS光谱仪上工作在70 ev。薄层色谱采用E-Merch预涂硅胶板(60F-254)，碘作为显影剂。Acme，印度硅胶，60-120目用于柱层析。所有化合物通过柱层析纯化，使用硅胶(60-120目)用甲醇中(50:1)的二氯甲烷洗脱。结论建立了一种合成甲基-2-(n -乙基- n -苯基氨基)萘啶-3-羧酸盐的高效方法。
A facile synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates
Objective
To develop an efficient method for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates which is suitable for different naphthyridines.
Methods
All reagents used were commercial grade, 1H NMR spectra were obtained on a varian 400 MHz instrument with TMS as internal standard and chemical shifts are expressed δ ppm solvent used in DMSO-d6 & CDCl3 and LC–MS spectrum on a Waters LC–MS spectrometer operating at 70 ev. TLC is performed with E-Merch precoated silica gel plates (60F-254) with iodine as a developing agent. Acme, India silica gel, 60–120 mesh for column chromatography is used. All compounds are purified by column chromatography by using Silica gel (60–120 mesh) eluted with (50:1) dichloromethane in methanol.
Conclusions
We have developed an efficient protocol for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates.
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