Akihiro Tokunaga, D. Sugiyama, Y. Maeda, A. B. Warner, K. Panageas, S. Ito, Y. Togashi, Chika Sakai, J. Wolchok, H. Nishikawa
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Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids
Corticosteroids inhibit antitumor immune responses of immune checkpoint blockade in a dose- and timing-dependent manner. Memory CD8+ T cells with low TCR affinity are selectively suppressed by corticosteroids, necessitating careful and thoughtful corticosteroid use.
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