Yifan Zhou, Yusra B Medik, B. Patel, D. Zamler, Sijie Chen, T. Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, E. Park, Alexandria P. Cogdill, Daniel H Johnson, Sarah B. Johnson, K. Wani, D. Ledesma, C. Hudgens, Jingjing Wang, M. A. W. Khan, Aron Y Joon, W. Peng, Haiyan S. Li, R. Arora, Ximing Tang, M. G. Raso, Xuegong Zhang, W. Foo, M. Tetzlaff, G. Diehl, K. Clise-Dwyer, Elizabeth M Whitley, M. Gubin, J. Allison, P. Hwu, N. Ajami, A. Diab, J. Wargo, S. Watowich
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Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration
Zhou et al. establish murine models of anti-CTLA-4–mediated intestinal irAEs. These reveal common immune signatures and the importance of fecal microbiome dysbiosis as irAE-driving mechanisms, which enable preclinical therapeutic interventions. Key immune features are validated in a cohort of melanoma patients with ICB-associated intestinal irAEs.
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