必需营养素牛磺酸对苯并(a)芘诱发实验性肺癌的抗氧化作用及化学预防作用

Sivabalan Venkatachalam, Periyyasamy Kuppusamy, Baskaran Kuppusamy, Sakthisekaran Dhanapal
{"title":"必需营养素牛磺酸对苯并(a)芘诱发实验性肺癌的抗氧化作用及化学预防作用","authors":"Sivabalan Venkatachalam,&nbsp;Periyyasamy Kuppusamy,&nbsp;Baskaran Kuppusamy,&nbsp;Sakthisekaran Dhanapal","doi":"10.1016/j.bionut.2013.09.006","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Lung cancer is a major cause of morbidity and mortality worldwide both in men and women accounting for 29% of all other cancers. The constituents of smoke consist of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene which play a major role in lung carcinogenesis. B(a)P increases oncogenic stimulation by enhancing intrinsic </span>ROS stress and metabolic activity. Recent focus of cancer </span>chemoprevention is on the supplementation of natural anti-oxidants which are capable of ameliorating biochemical and molecular changes that occur during carcinogenesis. Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid abundant in sea foods has potent antioxidant property. The present study was framed to investigate the potency of taurine on boosting the antioxidant status and chemopreventive effect against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Administration of B(a)P (50</span> <span>mg/kg body weight) to mice resulted in decrease in the activities of enzymic and non-enzymic anti-oxidants with concomitant increase in lipid peroxides<span> (LPO), protein carbonyls and lung specific tumor markers. Taurine supplementation (100</span></span> <!-->mg/kg body weight) significantly attenuated these alterations. From these results, we suggest that administration of B(a)P induces ROS production and diminishes antioxidant levels. Conversely, taurine affords protection from ROS induced lung damage by augmenting the function of anti-oxidants.</p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 2","pages":"Pages 251-255"},"PeriodicalIF":0.0000,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.09.006","citationCount":"7","resultStr":"{\"title\":\"The potency of essential nutrient taurine on boosting the antioxidant status and chemopreventive effect against benzo (a)pyrene induced experimental lung cancer\",\"authors\":\"Sivabalan Venkatachalam,&nbsp;Periyyasamy Kuppusamy,&nbsp;Baskaran Kuppusamy,&nbsp;Sakthisekaran Dhanapal\",\"doi\":\"10.1016/j.bionut.2013.09.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>Lung cancer is a major cause of morbidity and mortality worldwide both in men and women accounting for 29% of all other cancers. The constituents of smoke consist of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene which play a major role in lung carcinogenesis. B(a)P increases oncogenic stimulation by enhancing intrinsic </span>ROS stress and metabolic activity. Recent focus of cancer </span>chemoprevention is on the supplementation of natural anti-oxidants which are capable of ameliorating biochemical and molecular changes that occur during carcinogenesis. Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid abundant in sea foods has potent antioxidant property. The present study was framed to investigate the potency of taurine on boosting the antioxidant status and chemopreventive effect against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Administration of B(a)P (50</span> <span>mg/kg body weight) to mice resulted in decrease in the activities of enzymic and non-enzymic anti-oxidants with concomitant increase in lipid peroxides<span> (LPO), protein carbonyls and lung specific tumor markers. Taurine supplementation (100</span></span> <!-->mg/kg body weight) significantly attenuated these alterations. From these results, we suggest that administration of B(a)P induces ROS production and diminishes antioxidant levels. Conversely, taurine affords protection from ROS induced lung damage by augmenting the function of anti-oxidants.</p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":\"4 2\",\"pages\":\"Pages 251-255\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2013.09.006\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210523913000627\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000627","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7

摘要

肺癌是全世界男性和女性发病和死亡的主要原因,占所有其他癌症的29%。烟雾的成分包括多环芳烃(PAHs),如苯并(a)芘,它在肺癌发生中起主要作用。B(a)P通过增强内在ROS应激和代谢活性增加致癌刺激。最近癌症化学预防的重点是补充天然抗氧化剂,这些抗氧化剂能够改善致癌过程中发生的生化和分子变化。牛磺酸(2-氨基乙磺酸)是海产品中富含的一种含硫β-氨基酸,具有很强的抗氧化性能。本研究旨在探讨牛磺酸在提高瑞士白化小鼠抗氧化能力和抗苯并(a)芘诱发肺癌的化学预防作用。给小鼠B(a)P (50 mg/kg体重)导致酶和非酶抗氧化剂活性降低,同时脂质过氧化物(LPO)、蛋白质羰基和肺特异性肿瘤标志物升高。补充牛磺酸(100 mg/kg体重)可显著减弱这些变化。从这些结果来看,我们认为B(a)P可以诱导ROS的产生并降低抗氧化水平。相反,牛磺酸通过增强抗氧化剂的功能,对ROS诱导的肺损伤提供保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The potency of essential nutrient taurine on boosting the antioxidant status and chemopreventive effect against benzo (a)pyrene induced experimental lung cancer

Lung cancer is a major cause of morbidity and mortality worldwide both in men and women accounting for 29% of all other cancers. The constituents of smoke consist of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene which play a major role in lung carcinogenesis. B(a)P increases oncogenic stimulation by enhancing intrinsic ROS stress and metabolic activity. Recent focus of cancer chemoprevention is on the supplementation of natural anti-oxidants which are capable of ameliorating biochemical and molecular changes that occur during carcinogenesis. Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid abundant in sea foods has potent antioxidant property. The present study was framed to investigate the potency of taurine on boosting the antioxidant status and chemopreventive effect against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Administration of B(a)P (50 mg/kg body weight) to mice resulted in decrease in the activities of enzymic and non-enzymic anti-oxidants with concomitant increase in lipid peroxides (LPO), protein carbonyls and lung specific tumor markers. Taurine supplementation (100 mg/kg body weight) significantly attenuated these alterations. From these results, we suggest that administration of B(a)P induces ROS production and diminishes antioxidant levels. Conversely, taurine affords protection from ROS induced lung damage by augmenting the function of anti-oxidants.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats Antidiabetic therapeutics from natural source: A systematic review Insignificant viability of the granules of probiotic and prebiotic with skimmed milk powder Protective role of Solanum trilobatum (Solanaeace) against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice Molecular docking, isolation and biological evaluation of Rhizophora mucronata flavonoids as anti-nociceptive agents
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1