必需营养素牛磺酸对苯并(a)芘诱发实验性肺癌的抗氧化作用及化学预防作用

Sivabalan Venkatachalam, Periyyasamy Kuppusamy, Baskaran Kuppusamy, Sakthisekaran Dhanapal
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引用次数: 7

摘要

肺癌是全世界男性和女性发病和死亡的主要原因,占所有其他癌症的29%。烟雾的成分包括多环芳烃(PAHs),如苯并(a)芘,它在肺癌发生中起主要作用。B(a)P通过增强内在ROS应激和代谢活性增加致癌刺激。最近癌症化学预防的重点是补充天然抗氧化剂,这些抗氧化剂能够改善致癌过程中发生的生化和分子变化。牛磺酸(2-氨基乙磺酸)是海产品中富含的一种含硫β-氨基酸,具有很强的抗氧化性能。本研究旨在探讨牛磺酸在提高瑞士白化小鼠抗氧化能力和抗苯并(a)芘诱发肺癌的化学预防作用。给小鼠B(a)P (50 mg/kg体重)导致酶和非酶抗氧化剂活性降低,同时脂质过氧化物(LPO)、蛋白质羰基和肺特异性肿瘤标志物升高。补充牛磺酸(100 mg/kg体重)可显著减弱这些变化。从这些结果来看,我们认为B(a)P可以诱导ROS的产生并降低抗氧化水平。相反,牛磺酸通过增强抗氧化剂的功能,对ROS诱导的肺损伤提供保护。
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The potency of essential nutrient taurine on boosting the antioxidant status and chemopreventive effect against benzo (a)pyrene induced experimental lung cancer

Lung cancer is a major cause of morbidity and mortality worldwide both in men and women accounting for 29% of all other cancers. The constituents of smoke consist of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene which play a major role in lung carcinogenesis. B(a)P increases oncogenic stimulation by enhancing intrinsic ROS stress and metabolic activity. Recent focus of cancer chemoprevention is on the supplementation of natural anti-oxidants which are capable of ameliorating biochemical and molecular changes that occur during carcinogenesis. Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid abundant in sea foods has potent antioxidant property. The present study was framed to investigate the potency of taurine on boosting the antioxidant status and chemopreventive effect against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Administration of B(a)P (50 mg/kg body weight) to mice resulted in decrease in the activities of enzymic and non-enzymic anti-oxidants with concomitant increase in lipid peroxides (LPO), protein carbonyls and lung specific tumor markers. Taurine supplementation (100 mg/kg body weight) significantly attenuated these alterations. From these results, we suggest that administration of B(a)P induces ROS production and diminishes antioxidant levels. Conversely, taurine affords protection from ROS induced lung damage by augmenting the function of anti-oxidants.

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