替诺福韦抗hiv药物分析方法开发与验证技术研究进展

Shweta B. Avhad, Vidya Morkar, Sagar I. Shinde, Chaitanya patki, Hemant U Chikhale, L. Borse
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引用次数: 1

摘要

关于获得性免疫缺陷综合症(艾滋病)的管理提出了许多问题,艾滋病是由一种称为艾滋病毒的逆转录病毒引起的,(人类免疫缺陷病毒)是导致艾滋病的原因。艾滋病毒引起的感染尤其是世界上最严重的健康和发展挑战。虽然目前还没有完全治愈艾滋病毒的方法,但有几种药物可以通过降低体内艾滋病毒的数量来帮助你保持健康。在治疗艾滋病毒感染时,使用抗逆转录病毒疗法,这类药物中有多种药物可供使用。替诺福韦及其盐版本,无论是单独使用还是与恩曲他滨联合使用,都是最常用的药物。应该降低艾滋病毒水平,这样你的免疫系统才能更有效地运作。这篇文章提供了总结和评价的几种分析技术用于抗逆转录病毒药物替诺福韦在过去的五年。它包括强制降解,HPLC和RP-HPLC, HPTLC, UPLC和RP-UPLC, LC-MS。
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Recent Advances in Analytical Method Development and Validation Techniques for Anti-HIV Pharmaceuticals of Tenofovir
Many questions have been raised regarding the management of acquired immunodeficiency syndrome (AIDS) which is caused by a retrovirus called as HIV, (human immunodeficiency virus) is what causes AIDS. Infection caused by HIV is particularly the world's most serious health and development challenges. Although there is no known complete cure for HIV, several drugs can help you stay healthy by lowering the amount of HIV in your body. When treating HIV infection, antiretroviral therapy is used, and a variety of medications are available from this category. Tenofovir and its salt versions, both by themselves and in combination with emtricitabine, are the most often utilized medications. HIV levels should be lowered so that your immune system can function more effectively. This article offers a summary and evaluation of several analytical techniques used on the antiretroviral medication tenofovir over the previous five years. It covers forced degradation, HPLC and RP-HPLC, HPTLC, UPLC and RP-UPLC, LC-MS.
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