E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova
{"title":"空间化配合物BIS(2-吡啶基)-3-(1,2,4-三唑基)丙烷和11-羟基-1,1-乙基二膦酸的生物筛选","authors":"E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova","doi":"10.2991/isils-19.2019.19","DOIUrl":null,"url":null,"abstract":"scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid\",\"authors\":\"E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova\",\"doi\":\"10.2991/isils-19.2019.19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats\",\"PeriodicalId\":20489,\"journal\":{\"name\":\"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2991/isils-19.2019.19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2991/isils-19.2019.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid
scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats
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