饮食干预通过ctcf介导的转录重编程保持小鼠β细胞功能

The Tokushima journal of experimental medicine Pub Date : 2022-06-02 DOI:10.1084/jem.20211779

Ruo-Ran Wang, Xinyuan Qiu, Ran Pan, Hongxing Fu, Ziyin Zhang, Qintao Wang, Haide Chen, Qing-Qian Wu, Xiaowen Pan, Yanping Zhou, Pengfei Shan, Shusen Wang, Guoji Guo, Min Zheng, Lingyun Zhu, Z. Meng

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引用次数: 12

摘要

Wang等人系统地描述了β细胞功能和转录组适应在饮食诱导的肥胖和T2D进展中的动态性质。他们还发现CTCF是通过转录重编程的饮食干预诱导的β细胞功能保存的关键介质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming

Wang et al. systematically characterize the dynamic nature of β cell functional and transcriptomic adaptation along the progression of diet-induced obesity and T2D. They also identify CTCF as a key mediator of dietary intervention–induced preservation β cell function via transcriptional reprogramming.

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The Tokushima journal of experimental medicine

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