{"title":"巯基亲核试剂与(E)-?-羟基-a，ß-不饱和亚砜和砜","authors":"I. Forristal, K. Lawson, C. Rayner","doi":"10.1080/0278611031000104989","DOIUrl":null,"url":null,"abstract":"The stereoselective conjugate addition of thiolate nucleophiles to γ-hydroxy-α,β-unsaturated sulfoxides and sulfones is reported. Moderate to good levels of diastereoselectivity are observed, with the two stereocontrolling elements, the hydroxyl group and the sulfoxide, showing reinforcing and nonreinforcing control of stereoselectivity, depending on their relative configuration.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Stereoselective conjugate addition of thiolate nucleophiles to (E)-?-hydroxy-a,ß-unsaturated sulfoxides and sulfones\",\"authors\":\"I. Forristal, K. Lawson, C. Rayner\",\"doi\":\"10.1080/0278611031000104989\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The stereoselective conjugate addition of thiolate nucleophiles to γ-hydroxy-α,β-unsaturated sulfoxides and sulfones is reported. Moderate to good levels of diastereoselectivity are observed, with the two stereocontrolling elements, the hydroxyl group and the sulfoxide, showing reinforcing and nonreinforcing control of stereoselectivity, depending on their relative configuration.\",\"PeriodicalId\":22122,\"journal\":{\"name\":\"Sulfur Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sulfur Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/0278611031000104989\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sulfur Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/0278611031000104989","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stereoselective conjugate addition of thiolate nucleophiles to (E)-?-hydroxy-a,ß-unsaturated sulfoxides and sulfones
The stereoselective conjugate addition of thiolate nucleophiles to γ-hydroxy-α,β-unsaturated sulfoxides and sulfones is reported. Moderate to good levels of diastereoselectivity are observed, with the two stereocontrolling elements, the hydroxyl group and the sulfoxide, showing reinforcing and nonreinforcing control of stereoselectivity, depending on their relative configuration.
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