伴随的PIK3CD和TNFRSF9缺陷导致T细胞的慢性活动性eb病毒感染

The Tokushima journal of experimental medicine Pub Date : 2019-09-19 DOI:10.1084/jem.20190678

Rémy Rodriguez, B. Fournier, D. J. Cordeiro, Sarah Winter, K. Izawa, Emmanuel Martin, D. Boutboul, C. Lenoir, S. Fraitag, S. Kracker, T. Watts, C. Picard, J. Bruneau, I. Callebaut, A. Fischer, B. Neven, S. Latour

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引用次数: 50

摘要

在慢性活动性eb病毒感染T细胞(CAEBV)的亲属中鉴定出TNFRSF9和PIK3CD双等位基因功能缺失突变，表明CAEBV是提供ebv感染T细胞生长优势的因素结合对ebv感染细胞的缺陷细胞免疫的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells

Identification of biallelic loss-of-function mutations in TNFRSF9 and PIK3CD in a kindred with chronic active Epstein-Barr virus infection of T cells (CAEBV) suggests that CAEBV is the consequence of factors providing growth advantage to EBV-infected T cells combined with defective cell immunity toward EBV-infected cells.

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The Tokushima journal of experimental medicine

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