在结肠炎相关结直肠癌的小鼠模型中，肠道微生物群的编辑减少了致癌作用

The Tokushima journal of experimental medicine Pub Date : 2019-07-29 DOI:10.1084/jem.20181939

Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter

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引用次数: 76

摘要

肠杆菌科成员如大肠杆菌会加剧肠道恶性肿瘤的发展。Zhu等人报道，钨酸盐靶向肠杆菌科原瘤代谢可阻止结肠炎相关结直肠癌小鼠模型的肿瘤发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.

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The Tokushima journal of experimental medicine

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