Synthesis, characterization and biological evaluation of acetazolamide, cycloserine and isoniazid condensed some novel phthalimide derivatives

Background/aim

In the present study, a series of novel phthalimide derivatives synthesized because of its potent antimicrobial and antimycobacterial activity.

Method

Structurally modified phthalimide derivatives were prepared through condensation of substituted phthalic anhydride with corresponding acetazolamide, cycloserine and isoniazid with variable yields. Synthesized Compounds (6a–d), (7a–d) and (8a–d) analyzed for their structures, in vitro antimicrobial and antimycobacterial activity.

Result

Among the synthesized compounds, compound 6b, 7b and 8b was found to be the most potent against Gram-positive bacteria Bacillus subtilis, Gram-negative bacteria Escherichia coli, Mycobacterium tuberculosis CIP and M. tuberculosis H37Rv.

Conclusion

A series of novel phthalimide derivatives of biological interest were synthesized and analyzed, suggests that it an interesting compound compared to the current therapeutic agents and are considered to investigate further for the same.