Vinayagam Magendira Mani , Abdul Majeeth Mohamed Sadiq
{"title":"柚皮苷调节溴氰菊酯暴露大鼠的记忆、焦虑、运动和情绪行为的损害;与氧化应激、乙酰胆碱酯酶和三磷酸腺苷酶有关的可能机制","authors":"Vinayagam Magendira Mani , Abdul Majeeth Mohamed Sadiq","doi":"10.1016/j.bionut.2014.08.006","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span><span>Exposure to pyrethroid pesticides has been associated with adverse neurodevelopmental outcomes, like </span>neurodegenerative disorder, low IQ, </span>pervasive developmental disorder<span><span><span>, attention problems. Thus, we investigated the relationship between pyrethroid deltamethrin exposure to </span>acetylcholine esterase, </span>ATPase, </span></span>oxidative stress<span> biomarkers, and impaired behavior performance, and the possible ameliorating mechanism of dietary flavonoid </span></span>naringin<span> in male Wistar rats. Adult male wistar rats were divided into four different groups. Group I: control group; group II received DLM dissolved in corn oil 12.8</span></span> <!-->mg/kg BW orally (1/10 LD<sub>50</sub>) for three weeks; group III received DLM as group II and naringin (100<!--> <!-->mg/kg BW for 21<!--> <!-->days) orally. Group IV: naringin alone. DLM exposure leads to reduction in the levels of acetylcholinesterase, Na<sup>+</sup>/K<sup>+</sup>, Ca<sup>2+</sup>, Mg<sup>2+</sup><span><span><span> ATPase, enzymic and non-enzymic antioxidants activities in cortex and </span>hippocampus region and increase the activities of </span>TBARS<span><span>. DLM-induced neuronal alterations was evidenced by impairment behavioral performance, like memory, anxiety, locomotor, and emotionality behaviors. This is also supported by histopathological findings of cortex and hippocampus region of rats. However, naringin </span>treatment<span><span> modulates the abnormalities of DLM-induced alterations in oxidative stress biomarkers, acetylcholine esterase, ATPase, and behavioral performance of rats. These findings highlight the efficacy of naringin as neuroprotectant. In conclusion, our results demonstrated that DLM cause neurobehavioral and biochemical alterations. Oxidative stress, free radical mechanism play major role on DLM-induced </span>neurotoxicity<span>. Naringin could be a suitable agent for preventing the toxicity of DLM by its potent antioxidant, free radical scavenging and neuroprotective activity.</span></span></span></span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.08.006","citationCount":"25","resultStr":"{\"title\":\"Naringin modulates the impairment of memory, anxiety, locomotor, and emotionality behaviors in rats exposed to deltamethrin; a possible mechanism association with oxidative stress, acetylcholinesterase and ATPase\",\"authors\":\"Vinayagam Magendira Mani , Abdul Majeeth Mohamed Sadiq\",\"doi\":\"10.1016/j.bionut.2014.08.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span><span>Exposure to pyrethroid pesticides has been associated with adverse neurodevelopmental outcomes, like </span>neurodegenerative disorder, low IQ, </span>pervasive developmental disorder<span><span><span>, attention problems. Thus, we investigated the relationship between pyrethroid deltamethrin exposure to </span>acetylcholine esterase, </span>ATPase, </span></span>oxidative stress<span> biomarkers, and impaired behavior performance, and the possible ameliorating mechanism of dietary flavonoid </span></span>naringin<span> in male Wistar rats. Adult male wistar rats were divided into four different groups. Group I: control group; group II received DLM dissolved in corn oil 12.8</span></span> <!-->mg/kg BW orally (1/10 LD<sub>50</sub>) for three weeks; group III received DLM as group II and naringin (100<!--> <!-->mg/kg BW for 21<!--> <!-->days) orally. Group IV: naringin alone. DLM exposure leads to reduction in the levels of acetylcholinesterase, Na<sup>+</sup>/K<sup>+</sup>, Ca<sup>2+</sup>, Mg<sup>2+</sup><span><span><span> ATPase, enzymic and non-enzymic antioxidants activities in cortex and </span>hippocampus region and increase the activities of </span>TBARS<span><span>. DLM-induced neuronal alterations was evidenced by impairment behavioral performance, like memory, anxiety, locomotor, and emotionality behaviors. This is also supported by histopathological findings of cortex and hippocampus region of rats. However, naringin </span>treatment<span><span> modulates the abnormalities of DLM-induced alterations in oxidative stress biomarkers, acetylcholine esterase, ATPase, and behavioral performance of rats. These findings highlight the efficacy of naringin as neuroprotectant. In conclusion, our results demonstrated that DLM cause neurobehavioral and biochemical alterations. Oxidative stress, free radical mechanism play major role on DLM-induced </span>neurotoxicity<span>. Naringin could be a suitable agent for preventing the toxicity of DLM by its potent antioxidant, free radical scavenging and neuroprotective activity.</span></span></span></span></p></div>\",\"PeriodicalId\":100182,\"journal\":{\"name\":\"Biomedicine & Preventive Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bionut.2014.08.006\",\"citationCount\":\"25\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine & Preventive Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221052391400083X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221052391400083X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Naringin modulates the impairment of memory, anxiety, locomotor, and emotionality behaviors in rats exposed to deltamethrin; a possible mechanism association with oxidative stress, acetylcholinesterase and ATPase
Exposure to pyrethroid pesticides has been associated with adverse neurodevelopmental outcomes, like neurodegenerative disorder, low IQ, pervasive developmental disorder, attention problems. Thus, we investigated the relationship between pyrethroid deltamethrin exposure to acetylcholine esterase, ATPase, oxidative stress biomarkers, and impaired behavior performance, and the possible ameliorating mechanism of dietary flavonoid naringin in male Wistar rats. Adult male wistar rats were divided into four different groups. Group I: control group; group II received DLM dissolved in corn oil 12.8 mg/kg BW orally (1/10 LD50) for three weeks; group III received DLM as group II and naringin (100 mg/kg BW for 21 days) orally. Group IV: naringin alone. DLM exposure leads to reduction in the levels of acetylcholinesterase, Na+/K+, Ca2+, Mg2+ ATPase, enzymic and non-enzymic antioxidants activities in cortex and hippocampus region and increase the activities of TBARS. DLM-induced neuronal alterations was evidenced by impairment behavioral performance, like memory, anxiety, locomotor, and emotionality behaviors. This is also supported by histopathological findings of cortex and hippocampus region of rats. However, naringin treatment modulates the abnormalities of DLM-induced alterations in oxidative stress biomarkers, acetylcholine esterase, ATPase, and behavioral performance of rats. These findings highlight the efficacy of naringin as neuroprotectant. In conclusion, our results demonstrated that DLM cause neurobehavioral and biochemical alterations. Oxidative stress, free radical mechanism play major role on DLM-induced neurotoxicity. Naringin could be a suitable agent for preventing the toxicity of DLM by its potent antioxidant, free radical scavenging and neuroprotective activity.