S. Di Biase, Xiaoya Ma, Xi Wang, Jiaji Yu, Yu-Chen Wang, Drake J. Smith, Yang Zhou, Zhe Li, Y. J. Kim, N. Clarke, Angela To, Lili Yang
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引用次数: 55
摘要
Di Biase等人首次表明，肌酸作为一种“分子电池”，保存生物能量，为CD8 T细胞活动提供动力;肌酸摄取对支持抗肿瘤T细胞免疫至关重要;补充肌酸有望改善癌症免疫治疗。
Creatine uptake regulates CD8 T cell antitumor immunity
Di Biase et al. show for the first time that creatine acts as a “molecular battery” conserving bioenergy to power CD8 T cell activities; that creatine uptake is critical in supporting antitumor T cell immunity; and that creatine supplementation holds promise for improving cancer immunotherapy.
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