果蝇发育过程中的细胞周期变异及其控制

Christian F. Lehner
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引用次数: 1

摘要

对于发育生物学来说,细胞周期最相关的方面可能是它并不是一个真正完美的周期。从一个细胞到两个细胞,这个循环并没有完全在它开始的地方结束,但它为多细胞生物的构建提供了基础。细胞周期的进入、进展和退出在发育过程中受到控制,以便在正确的空间和时间模式中产生足够的细胞。G1-和g2 -周期蛋白依赖性激酶控制着细胞周期的进程,因此预计会受到发育输入的调节。对果蝇的分析揭示了在连续发育阶段不同细胞周期类型中控制这些激酶复合物活性的多种机制。
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Cell cycle variants and their control during Drosophila development

For developmental biology, the most relevant aspect of the cell cycle is presumably the fact that it is not really a perfect cycle. By going from one to two cells, the cycle does not end exactly where it started, but it contributes building blocks for the construction of multicellular organisms. Entry into, progression through, and exit from the cell cycle are controlled during development in order to generate sufficient cells in the correct spatial and temporal pattern. G1- and G2-cyclin-dependent kinases, which govern the progression through the cell cycle, are expected therefore to be regulated by developmental inputs. Analyses in Drosophila have revealed a variety of mechanisms that control the activity of these kinase complexes in different cell cycle types at successive developmental stages.

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