Assay of some non-steroidal anti-inflammatory drugs with ammonium hexanitratocerate (IV) reagent

In the present paper we have reported a simple and convenient titrimetric method for determination of non-steroidal anti-inflammatory drugs (NSAIDs) e.g. aceclofenac, diclofenac sodium, ibuprofen, mefenamic acid and nimesulide in pure form and in their pharmaceutical preparations such as acecloren (Tab), aclofen (Tab), voveran (Tab), diclomax (Inj), brufen (Tab), norswell (Tab), meftal (Tab), mef-T (Tab), nicip-DT (Tab) and dolamide (Tab) with ammonium hexanitratocerate (AHC) reagent. It is a versatile oxidizing agent of cerium (IV) and is being widely used as an oxidant for several classes of organic compounds. During estimation it was noted that the excipients present in pharmaceutical preparations do not interfere. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method.