Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort.

IF 3.8 4区医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2024-08-01 Epub Date: 2023-09-08 DOI:10.1017/neu.2023.45

Seetal Dodd, Mohammedreza Mohebbi, Josie O'Donohue, Gail Matthews, David R Darley, Michael Berk

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Abstract

A relationship between SARS-CoV-2 infection and psychiatric symptoms has been identified but is still being fully investigated. Neuropsychiatric sequalae have been reported for several infectious agents and are not unexpected for SARS-CoV-2 infection. This study follows for 12 months a sample (N = 144) of people who have had a confirmed infection of SARS-CoV-2. Medical and neuropsychiatric data and biological specimens are collected at 6 study visits. The 34-item SPHERE questionnaire, the Depression in the Medically Ill instrument, the EQ-5D-5L quality of life instrument and the visual analogue scale of fatigue were administered at multiple timepoints and associations with measures of illness and inflammatory biomarkers were investigated using the generalised estimating equation. Associations between inflammatory biomarkers and mental health measures of various effect sizes were identified. A robust inverse association was found between mental health outcomes and long covid status, but not between mental health outcomes and covid illness severity. This study suggests that long covid may be the strongest predictor of neuropsychiatric symptoms amongst people who have been infected with SARS-CoV-2.

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SARS-Cov-2感染后的精神后遗症:澳大利亚纵向队列中的轨迹、预测因素和关联

已经确定了SARS-CoV-2感染与精神症状之间的关系，但仍在全面调查中。已经报道了几种感染因子的神经精神后遗症，并且对于SARS-CoV-2感染并不意外。这项研究对确认感染SARS-CoV-2的人进行了12个月的跟踪调查(N = 144)。在6次研究访问中收集了医学和神经精神数据以及生物标本。在多个时间点使用34项SPHERE问卷、疾病抑郁量表、EQ-5D-5L生活质量量表和疲劳视觉模拟量表，并使用广义估计方程调查与疾病测量和炎症生物标志物的关联。确定了炎症生物标志物与各种效应量的心理健康测量之间的关联。心理健康结果与长期covid状态之间存在显著的负相关，但心理健康结果与covid疾病严重程度之间没有显著的负相关。这项研究表明，长covid可能是感染了SARS-CoV-2的人神经精神症状的最强预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica 医学-精神病学

CiteScore

8.50

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.