Antiviral activity of terpenes isolated from marine brown seaweeds against herpes simplex virus type 2

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-16 DOI:10.1080/14786419.2023.2288234

Lorena da Graça Pedrosa de Macena , Leonardo dos Santos Corrêa Amorim , Kauê Francisco Corrêa de Souza e Souza , Luíza Dantas Pereira , Claudio Cesar Cirne dos Santos , Caroline de Souza Barros , Carlos José Brito Ramos , Marcos Vinicius Santana , Helena Carla Castro , Valéria Laneuville Teixeira , Ana Maria Viana Pinto , Helena de Souza Pereira , Izabel Christina Nunes de Palmer Paixão

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Abstract

Herpes simplex virus type 2 (HSV-2) is the most common agent of sexually transmitted infections around the world. Currently, no vaccine is available, and acyclovir is the reference compound in treatment HSV-2 infections. However, the emergence of resistant strains has reduced the efficacy in treatment. Several studies have shown marine seaweed biological activities, but there are no studies yet about the activity anti-HSV-2 of two its secundary metabolites, atomaric acid (1) and marine dolastane (2), isolated from Stypopodium zonale and Canistrocarpus cervicornis respectively. Therefore, we evaluated the anti-HSV-2 activity of compounds 1 and 2. Both compounds showed anti-HSV-2 activity with low cytotoxicity and compound 1 inactivated 90% of the viral particles at 50 µM. Both compounds inhibited the penetration and results in silico indicated the compound 1 as possible therapy alternative anti -HSV-2.

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从海洋棕色海藻中分离出的萜类化合物对 2 型单纯疱疹病毒的抗病毒活性。

单纯疱疹病毒 2 型（HSV-2）是全球最常见的性传播感染病原体。目前还没有疫苗，阿昔洛韦是治疗 HSV-2 感染的首选药物。然而，耐药菌株的出现降低了治疗效果。一些研究显示了海洋海藻的生物活性，但目前还没有关于分别从Stypopodium zonale和Canistrocarpus cervicornis中分离出的两种海洋海藻次生代谢产物--atomaric acid（1）和marine dolastane（2）的抗HSV-2活性的研究。因此，我们评估了化合物 1 和 2 的抗 HSV-2 活性。两种化合物都显示出低细胞毒性的抗 HSV-2 活性，化合物 1 在 50 µM 的浓度下能灭活 90% 的病毒颗粒。这两种化合物都抑制了病毒的渗透，而且硅学研究结果表明化合物 1 可以作为抗 HSV-2 的替代疗法。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.