Ionic Liquids Nanoliposomes Based on Targeted and Active Permeability for Enhanced Combination Chemotherapy Efficiency

Abstract

Tumor microenvironment severely restricts the delivery of chemotherapy drugs. The microenvironment responsive nanoparticles often have complex designs with hampered clinical translatability. Here, we show a kind of ionic liquids (ILs) with soybean lecithin (SL) as cation, folic acid (FA) as anion, in particular, it could formulate nanoliposome by film evaporation method to deliver cis-Diamineplatinum (II) dichloride (cisplatin, Cis) and doxorubicin hydrochloride (DOX). These special ILs liposome could target tumor cells via folate receptor-mediated endocytosis by enhancing the cellular uptake, and significantly improve the deep permeability by actively infiltrating throughout the tumor tissue owing to the special noncovalent bond between SL–FA ILs with cell membrane. Moreover, ILs liposomes improve delivery efficiency of Cis and DOX and enhance the combined chemotherapeutic effect. The simple preparation process of the ILs nanoliposome should facilitate the clinical transformation of nanodrugs.