A Review of Fucoxanthin Biomanufacturing from Phaeodactylum tricornutum.

IF 3.5 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Bioprocess and Biosystems Engineering Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI:10.1007/s00449-024-03039-8

Yunlong Pang, LiQin Duan, Bo Song, YuLin Cui, XiaoYong Liu, TingTing Wang

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Abstract

Microalgae, compared to macroalgae, exhibit advantages such as rapid growth rates, feasible large-scale cultivation, and high fucoxanthin content. Among these microalgae, Phaeodactylum tricornutum emerges as an optimal source for fucoxanthin production. This paper comprehensively reviews the research progress on fucoxanthin production using Phaeodactylum tricornutum from 2012 to 2022, offering detailed insights into various aspects, including strain selection, media optimization, nutritional requirements, lighting conditions, cell harvesting techniques, extraction solvents, extraction methodologies, as well as downstream separation and purification processes. Additionally, an economic analysis is performed to assess the costs of fucoxanthin production from Phaeodactylum tricornutum, with a comparative perspective to astaxanthin production from Haematococcus pluvialis. Lastly, this paper discusses the current challenges and future opportunities in this research field, serving as a valuable resource for researchers, producers, and industry managers seeking to further advance this domain.

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从三角藻中提取岩藻黄质生物制造技术综述。

与大型藻类相比，微藻类具有生长速度快、可进行大规模栽培、岩藻黄质含量高等优点。在这些微藻中，三尖杉藻（Phaeodactylum tricornutum）是生产狐黄素的最佳来源。本文全面回顾了2012年至2022年利用三角藻生产岩藻黄质的研究进展，从菌株选择、培养基优化、营养要求、光照条件、细胞收获技术、提取溶剂、提取方法以及下游分离和纯化工艺等多个方面进行了详细阐述。此外，本文还进行了经济分析，以评估利用三角藻生产岩藻黄质的成本，并与利用血球藻生产虾青素进行了比较。最后，本文讨论了这一研究领域当前面临的挑战和未来的机遇，为寻求进一步推动这一领域发展的研究人员、生产者和行业管理者提供了宝贵的资源。

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来源期刊

Bioprocess and Biosystems Engineering 工程技术-工程：化工

CiteScore

7.90

自引率

2.60%

发文量

147

审稿时长

2.6 months

期刊介绍： Bioprocess and Biosystems Engineering provides an international peer-reviewed forum to facilitate the discussion between engineering and biological science to find efficient solutions in the development and improvement of bioprocesses. The aim of the journal is to focus more attention on the multidisciplinary approaches for integrative bioprocess design. Of special interest are the rational manipulation of biosystems through metabolic engineering techniques to provide new biocatalysts as well as the model based design of bioprocesses (up-stream processing, bioreactor operation and downstream processing) that will lead to new and sustainable production processes. Contributions are targeted at new approaches for rational and evolutive design of cellular systems by taking into account the environment and constraints of technical production processes, integration of recombinant technology and process design, as well as new hybrid intersections such as bioinformatics and process systems engineering. Manuscripts concerning the design, simulation, experimental validation, control, and economic as well as ecological evaluation of novel processes using biosystems or parts thereof (e.g., enzymes, microorganisms, mammalian cells, plant cells, or tissue), their related products, or technical devices are also encouraged. The Editors will consider papers for publication based on novelty, their impact on biotechnological production and their contribution to the advancement of bioprocess and biosystems engineering science. Submission of papers dealing with routine aspects of bioprocess engineering (e.g., routine application of established methodologies, and description of established equipment) are discouraged.