Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer.

IF 3.5 2区 医学 Q2 ONCOLOGY Cancer Imaging Pub Date : 2024-07-08 DOI:10.1186/s40644-024-00723-6
Karoline Kallis, Christopher C Conlin, Allison Y Zhong, Troy S Hussain, Aritrick Chatterjee, Gregory S Karczmar, Rebecca Rakow-Penner, Anders M Dale, Tyler M Seibert
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Abstract

Background: High b-value diffusion-weighted images (DWI) are used for detection of clinically significant prostate cancer (csPCa). This study qualitatively and quantitatively compares synthesized DWI (sDWI) to acquired (aDWI) for detection of csPCa.

Methods: One hundred fifty-one consecutive patients who underwent prostate MRI and biopsy were included in the study. Axial DWI with b = 0, 500, 1000, and 2000 s/mm2 using a 3T clinical scanner using a 32-channel phased-array body coil were acquired. We retrospectively synthesized DWI for b = 2000 s/mm2 via extrapolation based on mono-exponential decay, using b = 0 and b = 500 s/mm2 (sDWI500) and b = 0, b = 500 s/mm2, and b = 1000 s/mm2 (sDWI1000). Differences in signal intensity between sDWI and aDWI were evaluated within different regions of interest (prostate alone, prostate plus 5 mm, 30 mm and 70 mm margin and full field of view). The maximum DWI value within each ROI was evaluated for prediction of csPCa. Classification accuracy was compared to Restriction Spectrum Imaging restriction score (RSIrs), a previously validated biomarker based on multi-exponential DWI. Discrimination of csPCa was evaluated via area under the receiver operating characteristic curve (AUC).

Results: Within the prostate, mean ± standard deviation of percent mean differences between sDWI and aDWI signal were -46 ± 35% for sDWI1000 and -67 ± 24% for sDWI500. AUC for aDWI, sDWI500, sDWI1000, and RSIrs within the prostate 0.62[95% confidence interval: 0.53, 0.71], 0.63[0.54, 0.72], 0.65[0.56, 0.73] and 0.78[0.71, 0.86], respectively.

Conclusion: sDWI is qualitatively comparable to aDWI within the prostate. However, hyperintense artifacts are introduced with sDWI in the surrounding pelvic tissue that interfere with quantitative cancer detection and might mask metastases. In the prostate, RSIrs yields superior quantitative csPCa detection than sDWI or aDWI.

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比较合成和获取的高 b 值弥散加权磁共振成像在检测前列腺癌方面的应用。
背景:高b值弥散加权成像(DWI)用于检测有临床意义的前列腺癌(csPCa)。本研究对合成 DWI(sDWI)和获取的 DWI(aDWI)进行了定性和定量比较,以检测 csPCa:研究纳入了 151 名连续接受前列腺 MRI 和活检的患者。我们使用一台使用 32 通道相控阵体线圈的 3T 临床扫描仪采集了 b = 0、500、1000 和 2000 s/mm2 的轴向 DWI。我们通过基于单指数衰减的外推法,使用 b = 0 和 b = 500 s/mm2(sDWI500)以及 b = 0、b = 500 s/mm2 和 b = 1000 s/mm2(sDWI1000)回顾性地合成了 b = 2000 s/mm2 的 DWI。在不同的感兴趣区(单独前列腺、前列腺加 5 毫米、30 毫米和 70 毫米边缘以及全视野)内评估 sDWI 和 aDWI 信号强度的差异。对每个区域内的最大 DWI 值进行评估,以预测 csPCa。分类准确性与限制性频谱成像限制性评分(RSIrs)进行了比较,后者是之前基于多指数 DWI 验证过的生物标记物。通过接收者操作特征曲线下面积(AUC)对 csPCa 的判别进行评估:结果:在前列腺内,sDWI1000 和 sDWI500 的 sDWI 和 aDWI 信号平均差异百分比的平均值(标准差)分别为 -46 ± 35% 和 -67 ± 24%。前列腺内 aDWI、sDWI500、sDWI1000 和 RSIrs 的 AUC 分别为 0.62[95%置信区间:0.53,0.71]、0.63[0.54,0.72]、0.65[0.56,0.73] 和 0.78[0.71,0.86]。结论:在前列腺内,sDWI 的质量与 aDWI 相当,但在盆腔周围组织中,sDWI 会产生高强度伪影,干扰癌症的定量检测,并可能掩盖转移灶。在前列腺中,RSIrs 对 csPCa 的定量检测优于 sDWI 或 aDWI。
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来源期刊
Cancer Imaging
Cancer Imaging ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
7.00
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology. The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include: Breast Imaging Chest Complications of treatment Ear, Nose & Throat Gastrointestinal Hepatobiliary & Pancreatic Imaging biomarkers Interventional Lymphoma Measurement of tumour response Molecular functional imaging Musculoskeletal Neuro oncology Nuclear Medicine Paediatric.
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