Nanozyme-based sensors for cancer diagnosis

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology Biosensors and Bioelectronics: X Pub Date : 2024-07-02 DOI:10.1016/j.biosx.2024.100512

Olga Guliy, Lev Dykman

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Abstract

Many biosensor technologies that can precisely and sensitively identify biomarkers reflecting disease status are being developed to help with early cancer detection and anticancer treatment monitoring. The creation of sensors based on nanozymes is one of the novel approaches in the intricate diagnosis and treatment of cancers. Because natural enzyme sensors can be unstable and expensive, the use of nanozymes in biosensors offers a great substitute for this type of study. Nanozymes have a stable shelf life, great operational reliability, cheap cost, and outstanding catalytic activity. The technological approaches to generating nanozymes and their use in sensors are briefly described in the paper. A summary of the many kinds of biosensors based on diverse kinds of nanomaterials for the identification of cancer biomarkers is provided, along with a discussion of the latest developments and challenges in the field of nanozyme biosensors for use in cancer diagnosis.

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基于纳米酶的癌症诊断传感器

目前正在开发许多生物传感器技术，以帮助早期癌症检测和抗癌治疗监测，这些技术能够精确、灵敏地识别反映疾病状态的生物标志物。基于纳米酶的传感器是癌症复杂诊断和治疗的新方法之一。由于天然酶传感器既不稳定又昂贵，在生物传感器中使用纳米酶为这类研究提供了一个很好的替代品。纳米酶具有稳定的保存期、极高的操作可靠性、低廉的成本和出色的催化活性。本文简要介绍了生成纳米酶的技术方法及其在传感器中的应用。本文概述了基于各种纳米材料的多种生物传感器，用于识别癌症生物标志物，并讨论了用于癌症诊断的纳米酶生物传感器领域的最新发展和挑战。

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.