{"title":"Molybdenum‐Catalyzed Intramolecular Deoxygenative Annulation of 2‐Acylazobenzenes to Access N2,C3‐Disubstituted 2H‐indazoles","authors":"Haoke Chu, Quanyun Liu, Mei-Hua Shen, Hua-Dong Xu","doi":"10.1002/adsc.202400662","DOIUrl":null,"url":null,"abstract":"A molybdenum‐catalyzed synthesis of N2,C3‐disubstituted 2H‐indazoles from readily available 2‐acylazobenzenes via deoxygenation of C=O and annulation has been described. The non‐noble metal catalytic system has good tolerance of functional groups, and various N2,C3‐disubstituted 2H‐indazoles have been constructed in 24% to 99% yield. This reaction is easy to scale‐up and has shown its applications in deriving valuable fluorescent and bioactive compounds. The plausible mechanism shows the plausible processes of molybdenum‐catalyzed deoxygenative annulation.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202400662","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A molybdenum‐catalyzed synthesis of N2,C3‐disubstituted 2H‐indazoles from readily available 2‐acylazobenzenes via deoxygenation of C=O and annulation has been described. The non‐noble metal catalytic system has good tolerance of functional groups, and various N2,C3‐disubstituted 2H‐indazoles have been constructed in 24% to 99% yield. This reaction is easy to scale‐up and has shown its applications in deriving valuable fluorescent and bioactive compounds. The plausible mechanism shows the plausible processes of molybdenum‐catalyzed deoxygenative annulation.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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