Thermoelectric catalysis overcomes tumour “marginalization” of cytotoxic T-lymphocytes to boost immune checkpoint blockade therapy

IF 13.2 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Today Pub Date : 2024-09-19 DOI:10.1016/j.nantod.2024.102500
{"title":"Thermoelectric catalysis overcomes tumour “marginalization” of cytotoxic T-lymphocytes to boost immune checkpoint blockade therapy","authors":"","doi":"10.1016/j.nantod.2024.102500","DOIUrl":null,"url":null,"abstract":"<div><p>Although immune checkpoint blockade (ICB) therapy enhances the tumour recognition of cytotoxic T lymphocytes (CTLs), the limited infiltration of CTLs into the centre of solid tumours significantly restricts the effect of ICB therapy. Herein, we showed that increased tumour interstitial fluid pressure (TIFP) is a critical factor in the tumour “marginalization” of CTLs. Additionally, we utilized a spatiotemporally controllable thermoelectric catalytic nanodrug (BF@M) to decompose water from the tumour interstitial fluid into oxygen, effectively reducing the TIFP and leading to enhanced infiltration of CTLs from the periphery to the interior of the solid tumour. The results revealed that BF@M significantly increased the intratumor infiltration of CTLs in three different tumour-bearing mouse models, with a maximum increase of 18.1 times. Overall, this study highlighted the intrinsic relationship between TIFP and CTLs infiltration and the mechanism underlying the effect of the TIFP, successfully addressing the tumour “marginalization” of CTLs to enhance ICB therapy.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224003566","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Although immune checkpoint blockade (ICB) therapy enhances the tumour recognition of cytotoxic T lymphocytes (CTLs), the limited infiltration of CTLs into the centre of solid tumours significantly restricts the effect of ICB therapy. Herein, we showed that increased tumour interstitial fluid pressure (TIFP) is a critical factor in the tumour “marginalization” of CTLs. Additionally, we utilized a spatiotemporally controllable thermoelectric catalytic nanodrug (BF@M) to decompose water from the tumour interstitial fluid into oxygen, effectively reducing the TIFP and leading to enhanced infiltration of CTLs from the periphery to the interior of the solid tumour. The results revealed that BF@M significantly increased the intratumor infiltration of CTLs in three different tumour-bearing mouse models, with a maximum increase of 18.1 times. Overall, this study highlighted the intrinsic relationship between TIFP and CTLs infiltration and the mechanism underlying the effect of the TIFP, successfully addressing the tumour “marginalization” of CTLs to enhance ICB therapy.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
热电催化克服肿瘤对细胞毒性 T 淋巴细胞的 "边缘化",促进免疫检查点阻断疗法的发展
尽管免疫检查点阻断(ICB)疗法能增强细胞毒性T淋巴细胞(CTL)对肿瘤的识别能力,但CTL对实体瘤中心的有限浸润大大限制了ICB疗法的效果。在这里,我们发现肿瘤间质压力(TIFP)的增加是CTLs被肿瘤 "边缘化 "的关键因素。此外,我们利用一种时空可控的热电催化纳米药物(BF@M)将肿瘤间质中的水分解成氧气,从而有效降低肿瘤间质压力,增强 CTL 从实体瘤外围向内部的渗透。研究结果表明,在三种不同的肿瘤小鼠模型中,BF@M 能显著增加 CTLs 在肿瘤内的浸润,最大增幅达 18.1 倍。总之,该研究强调了TIFP与CTLs浸润之间的内在关系以及TIFP的作用机制,成功地解决了CTLs被肿瘤 "边缘化 "的问题,从而提高了ICB的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nano Today
Nano Today 工程技术-材料科学:综合
CiteScore
21.50
自引率
3.40%
发文量
305
审稿时长
40 days
期刊介绍: Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.
期刊最新文献
Enhanced glomerular transfection by BMP7 gene nanocarriers inhibits CKD and promotes SOX9-dependent tubule regeneration Biomechanically matched and multistage hybrid porous scaffolds for stem cell-based osteochondral regeneration Dynamics of strong metal-support interactions: Investigating Pt and Pt-based alloys on CdS nanorods through experimental and simulated approaches Glucose-gated nanocoating endowing polyetheretherketone implants for enzymatic gas therapy to boost infectious diabetic osseointegration Atomic-scale imaging of structural evolution from anatase TiO2 to cubic TiO under electron beam irradiation
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1