Research progress on nanobodies in the diagnosis and treatment of natural toxin poisoning

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Today Pub Date : 2025-03-19 DOI:10.1016/j.nantod.2025.102711

Xiwei Wang , Zenglin Yin , Nan Liu , Hui Zhang , Zengming Wang , Jinjing Che , Jianchun Li , Aiping Zheng

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Abstract

Natural toxins pose a substantial threat to human health worldwide, with millions of individuals suffering from toxin poisoning annually. Rapid detection and efficient neutralization of these toxins are crucial to ensure human health. Nanobodies (Nbs) are a unique antibody type comprising only variable region fragments of the heavy chain. With properties such as small size, high stability, superior tissue penetration, and ease of production and modification, making Nbs are particularly advantageous in the diagnosis and treatment of natural toxin poisoning. This review outlines the current advancements in the modification of Nbs and highlights the research progress in addressing the diagnosis and treatment of poisoning caused by certain natural toxins. It underscores the potential of Nbs in this field, while also examining their benefits and associated challenges. By doing so, the study lays a robust groundwork for the future application of Nbs in combating natural toxin poisoning. Nbs could play an increasingly important role in diagnosing and treating natural toxin poisoning, contributing to the development of precision medicine.

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.