Research progress on nanobodies in the diagnosis and treatment of natural toxin poisoning

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Today Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI:10.1016/j.nantod.2025.102711

Xiwei Wang , Zenglin Yin , Nan Liu , Hui Zhang , Zengming Wang , Jinjing Che , Jianchun Li , Aiping Zheng

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Abstract

Natural toxins pose a substantial threat to human health worldwide, with millions of individuals suffering from toxin poisoning annually. Rapid detection and efficient neutralization of these toxins are crucial to ensure human health. Nanobodies (Nbs) are a unique antibody type comprising only variable region fragments of the heavy chain. With properties such as small size, high stability, superior tissue penetration, and ease of production and modification, making Nbs are particularly advantageous in the diagnosis and treatment of natural toxin poisoning. This review outlines the current advancements in the modification of Nbs and highlights the research progress in addressing the diagnosis and treatment of poisoning caused by certain natural toxins. It underscores the potential of Nbs in this field, while also examining their benefits and associated challenges. By doing so, the study lays a robust groundwork for the future application of Nbs in combating natural toxin poisoning. Nbs could play an increasingly important role in diagnosing and treating natural toxin poisoning, contributing to the development of precision medicine.

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纳米体在天然毒素中毒诊断与治疗中的研究进展

天然毒素对全世界人类健康构成重大威胁，每年有数百万人遭受毒素中毒。快速检测和有效中和这些毒素对确保人类健康至关重要。纳米抗体（Nbs）是一种独特的抗体类型，仅由重链的可变区域片段组成。Nbs具有体积小、稳定性高、穿透组织能力强、易于生产和修饰等特点，在天然毒素中毒的诊断和治疗方面尤其具有优势。本文综述了Nbs修饰的最新进展，重点介绍了Nbs在某些天然毒素中毒诊断和治疗方面的研究进展。它强调了Nbs在这一领域的潜力，同时也研究了它们的好处和相关挑战。通过这样做，该研究为Nbs在对抗天然毒素中毒方面的未来应用奠定了坚实的基础。Nbs可以在诊断和治疗天然毒素中毒方面发挥越来越重要的作用，为精准医学的发展做出贡献。

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.