Changes in health-related quality of life over the first three months of medical marijuana use.

IF 4.1 Q1 PHARMACOLOGY & PHARMACY Journal of cannabis research Pub Date : 2024-09-11 DOI:10.1186/s42238-024-00245-9
Michelle R Lent, Thomas R McCalmont, Megan M Short, Karen L Dugosh
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Abstract

Background: The psychosocial impact of medical marijuana use is not yet known. This study evaluated short-term changes in health-related quality of life (HRQoL) over the first three months of medical marijuana use.

Methods: This prospective, observational, longitudinal study followed adults newly recommended for medical marijuana by a physician for any of the more than 20 qualifying medical conditions in Pennsylvania. Participants (N = 438) provided their clinical status and demographic information, and completed semi-structured interviews prior to medical marijuana initiation (baseline) and at three months. HRQoL was assessed by the Short Form-36 (SF-36). Paired-samples t-tests evaluated changes in HRQoL over time.

Results: Participants (M age = 46.4 years [15.6]; 66.4% female) were mostly commonly referred for medical marijuana to treat anxiety disorders (61.9%) or severe chronic or intractable pain (53.6%). Participants reported rapid and significant improvements in all of the domains of HRQoL from baseline to three months after initiating medical marijuana use (physical functioning, role limitations due to physical health problems, emotional well-being, role limitations due to emotional problems, bodily pain, social functioning, energy/fatigue and general health, P < .001 for all). Age was negatively predictive of level of improvement over time for the physical functioning (P < .0001), role limitations due to physical health problems (P < .001), and pain (P < .0001) domains after controlling for baseline, with older participants displaying less improvement than younger participants.

Conclusions: Gains were observed in all HRQoL domains assessed after three months of medical marijuana use. In several domains, age was a significant predictor of degree of improvement.

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使用医用大麻头三个月中与健康相关的生活质量变化。
背景:使用医用大麻的社会心理影响尚不清楚。本研究评估了使用医用大麻头三个月内与健康相关的生活质量(HRQoL)的短期变化:这项前瞻性、观察性、纵向研究对宾夕法尼亚州新近被医生推荐使用医用大麻治疗 20 多种合格病症中任何一种病症的成年人进行了跟踪调查。参与者(N = 438)提供了他们的临床状况和人口统计学信息,并在开始使用医用大麻之前(基线)和三个月时完成了半结构化访谈。HRQoL 采用 Short Form-36 (SF-36) 进行评估。通过配对样本 t 检验评估了 HRQoL 随时间的变化:参与者(中位年龄 = 46.4 岁 [15.6];66.4% 为女性)大多被转介使用医用大麻治疗焦虑症(61.9%)或严重的慢性或顽固性疼痛(53.6%)。据参与者报告,从基线到开始使用医用大麻三个月后,他们在所有 HRQoL 领域(身体机能、因身体健康问题而受到的角色限制、情绪健康、因情绪问题而受到的角色限制、身体疼痛、社会功能、精力/疲劳和一般健康,P 结论)都得到了迅速而显著的改善:使用医用大麻三个月后,在所有 HRQoL 评估领域都观察到了进步。在多个领域,年龄是预测改善程度的重要因素。
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6.20
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