Xiaoqing Chen , Guoxing Xu , Xuemei Zhang , Chao Geng , Mengli Wang , Yang Fu , Zhen Lv , Shuai Wang , Zimeng Guo , Shixue Wang
{"title":"High-fidelity propionaldehyde functionalized Poly(ethylene glycol): Synthesis and applications","authors":"Xiaoqing Chen , Guoxing Xu , Xuemei Zhang , Chao Geng , Mengli Wang , Yang Fu , Zhen Lv , Shuai Wang , Zimeng Guo , Shixue Wang","doi":"10.1016/j.eurpolymj.2024.113489","DOIUrl":null,"url":null,"abstract":"<div><div>An economical and efficient approach for synthesizing high-fidelity PEG<sub>n</sub>-Alds through a substitution and oxidation process has been developed, providing a new pathway for obtaining high-purity PEG<sub>n</sub>-Alds, particularly addressing the issue of peroxidation and breakage of PEG main chains in the oxidation step. The synthesis of a series of high-fidelity PEG<sub>n</sub>-Alds with different functional groups or topological structures further proves the versatility of this new method. Additionally, PEG<sub>n</sub>-Alds also exhibit good biocompatibility, and potential ability to modify peptides and self-assembly to micelles, this lays a foundation for synthesizing high-quality drugs and developing novel therapeutics.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113489"},"PeriodicalIF":5.8000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S001430572400750X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
An economical and efficient approach for synthesizing high-fidelity PEGn-Alds through a substitution and oxidation process has been developed, providing a new pathway for obtaining high-purity PEGn-Alds, particularly addressing the issue of peroxidation and breakage of PEG main chains in the oxidation step. The synthesis of a series of high-fidelity PEGn-Alds with different functional groups or topological structures further proves the versatility of this new method. Additionally, PEGn-Alds also exhibit good biocompatibility, and potential ability to modify peptides and self-assembly to micelles, this lays a foundation for synthesizing high-quality drugs and developing novel therapeutics.
期刊介绍：
European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas:
Polymer synthesis and functionalization
• Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers.
Stimuli-responsive polymers
• Including shape memory and self-healing polymers.
Supramolecular polymers and self-assembly
• Molecular recognition and higher order polymer structures.
Renewable and sustainable polymers
• Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites.
Polymers at interfaces and surfaces
• Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications.
Biomedical applications and nanomedicine
• Polymers for regenerative medicine, drug delivery molecular release and gene therapy
The scope of European Polymer Journal no longer includes Polymer Physics.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
